Anti-ADAM17抗体
Anti-ADAM17 antibody
4
(6 Reviews)
|
(5 Publications)
Rabbit Polyclonal ADAM17 antibody. Suitable for IP, WB, ICC/IF and reacts with Rat, Pig, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM17.
查看别名
CD156b, CSVP, TACE, ADAM17, Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme
反应性数据
性能和储存信息
形式
纯化工艺
存储溶液
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The ADAM17 protein regulates a multitude of cellular responses such as inflammation and growth factor signaling. It is not part of a complex but interacts with various substrates in the cell membrane. ADAM17 cleaves precursors to release soluble cytokines and growth factors like tumor necrosis factor-alpha (TNF-alpha) and epidermal growth factor receptor (EGFR) ligands which modulate cell proliferation migration and apoptosis.
Pathways
ADAM17 plays an integral role in both the TNF and EGFR signaling pathways. These pathways are important in maintaining normal cellular homeostasis. ADAM17 interacts with proteins like TNF receptors and ligands of the EGFR family integrating signaling that affects immune response and cell growth. The regulatory function of ADAM17 in these pathways makes it an important target for modulating cellular responses triggered by external stimuli.
产品实验方案
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靶点信息
文献 (5)
Recent publications for all applications. Explore the full list and refine your search
Bone & joint research 11:763-776 PubMed36331083
2022
Applications
Unspecified application
Species
Unspecified reactive species
Scientific reports 12:11975 PubMed35831551
2022
Applications
Unspecified application
Species
Unspecified reactive species
Molecular and cellular biology 39: PubMed31208977
2019
Applications
Unspecified application
Species
Unspecified reactive species
Analytical biochemistry 449:68-75 PubMed24361716
2013
Applications
Unspecified application
Species
Unspecified reactive species
The Journal of biological chemistry 287:32578-87 PubMed22833676
2012
Applications
WB
Species
Unspecified reactive species
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