Anti-Activin Receptor Type IIB/ACVR2B抗体(ab128544)
Key features and details
- Rabbit polyclonal to Activin Receptor Type IIB/ACVR2B
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Activin Receptor Type IIB/ACVR2B抗体
参阅全部 Activin Receptor Type IIB/ACVR2B 一抗 -
描述
兔多克隆抗体to Activin Receptor Type IIB/ACVR2B -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Recombinant fragment corresponding to Human Activin Receptor Type IIB/ACVR2B aa 22-264. (BC096243)
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阳性对照
- K562 and PANC-1 cell lysates, Human fetal brain tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128544于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (1) |
1/1000 - 1/2000. Predicted molecular weight: 58 kDa.
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IHC-P |
1/100 - 1/500.
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说明 |
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WB
1/1000 - 1/2000. Predicted molecular weight: 58 kDa. |
IHC-P
1/100 - 1/500. |
靶标
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功能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. -
疾病相关
Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. -
序列相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 93 Human
- Entrez Gene: 11481 Mouse
- Omim: 602730 Human
- SwissProt: Q13705 Human
- SwissProt: P27040 Mouse
- Unigene: 174273 Human
- Unigene: 390239 Mouse
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别名
- Activin A receptor type IIB antibody
- Activin receptor type 2B antibody
- Activin receptor type IIB antibody
see all
图片
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All lanes : Anti-Activin Receptor Type IIB/ACVR2B antibody (ab128544) at 1/1000 dilution
Lane 1 : K562 cell lysate
Lane 2 : PANC-1 cell lysate
Predicted band size: 58 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIB/ACVR2B antibody (ab128544)
ab128544, at a dilution of 1/100, staining Activin Receptor Type IIB/ACVR2B in paraffin-embedded Human fetal brain tissue by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab128544 被引用在 8 文献中.
- Reichelt P et al. MicroRNA Expression Patterns Reveal a Role of the TGF-β Family Signaling in AML Chemo-Resistance. Cancers (Basel) 15:N/A (2023). PubMed: 37894453
- Xu J et al. TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair. J Neuroinflammation 20:50 (2023). PubMed: 36829205
- Desharnais P & Naud JF Detection of activin receptor type IIA and IIB-Fc fusion proteins by automated capillary immunoassay. Drug Test Anal 14:1938-1951 (2022). PubMed: 36200177
- Feng B et al. Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway via Acvr2b Suppression. Front Cell Dev Biol 8:568304 (2020). PubMed: 33763412
- Petrusel L et al. Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma. World J Gastrointest Oncol 11:1126-1140 (2019). PubMed: 31908718
- Castillero E et al. Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery. Am J Physiol Heart Circ Physiol 315:H1463-H1476 (2018). PubMed: 30141986
- Lin TT et al. Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries. Biol Reprod 98:683-694 (2018). PubMed: 29409020
- Galvão A et al. Nodal Promotes Functional Luteolysis via Down-Regulation of Progesterone and Prostaglandins E2 and Promotion of PGF2a Synthetic Pathways in Mare Corpus Luteum. Endocrinology 157:858-71 (2016). PubMed: 26653568