AB155981

重组Anti-Activin Receptor Type IA抗体[EPR4076(2)]

Name: Activin Receptor Type IA抗体[EPR4076(2)] (ab155981)| Abcam中文官网
Brand: Abcam Limited
SKU: AB155981
Price: 1521 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-Activin Receptor Type IA antibody [EPR4076(2)]

20ul selling size
RabMAb
Recombinant
了解详情

(1 Review)

(10 Publications)

Rabbit Recombinant Monoclonal Activin Receptor Type IA antibody. Suitable for IP, WB and reacts with Mouse, Rat, Human samples. Cited in 10 publications.

查看别名

ACVRLK2, ACVR1, Activin receptor type-1, Activin receptor type I, Activin receptor-like kinase 2, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I, ACTR-I, ALK-2, SKR1, TSR-I

4 Images

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Immunoprecipitation - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (AB155981)

ab155981 (purified) at 1 : 50 dilution (2μg) immunoprecipitating Activin Receptor Type IA in Mouse brain lysate.
Lane 1 (input) : Mouse brain lysate 10μg
Lane 2 (+) : ab155981 & Mouse brain lysate
Lane 3 (-) : Rabbit monoclonal IgG (ab172730) instead of ab155981 in Mouse brain lysate
For western blotting, VeriBlot for IP Detection Reagent (HRP) (ab131366) was used for detection at 1 : 1000 dilution.
Blocking and diluting buffer : 5% NFDM/TBST.

All lanes:

Immunoprecipitation - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (ab155981)

Predicted band size: 43 kDa,57 kDa

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Unknown

Western blot - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (AB155981)

Blocking and diluting buffer : 5% NFDM/TBST.

All lanes:

Western blot - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (ab155981) at 0.5 µg/mL

All lanes:

Human fetal brain lysates at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Predicted band size: 57 kDa

false

Unknown

Western blot - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (AB155981)

Blocking and diluting buffer : 5% NFDM/TBST.

All lanes:

Western blot - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (ab155981) at 0.5 µg/mL

Lane 1:

Mouse brain lysate at 15 µg

Lane 2:

Rat brain lysates at 15 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 57 kDa

false

Supplier Data

Western blot - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (AB155981)

All lanes:

Western blot - Anti-Activin Receptor Type IA antibody [EPR4076(2)] (ab155981) at 1/1000 dilution

Lane 1:

Fetal brain lysate at 10 µg

Lane 2:

Fetal heart lysate at 10 µg

Lane 3:

Fetal muscle lysate at 10 µg

Secondary

All lanes:

HRP labeled goat anti-rabbit IgG at 1/2000 dilution

Predicted band size: 57 kDa

Observed band size: 57 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-Activin Receptor Type IA antibody [EPR4076(2)] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR4076(2)

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

WB, IP

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Conditional Ambient

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Activin Receptor Type IA also known as ACVR1 or ALK2 is a type I receptor serine/threonine kinase. It has a mass of approximately 55 kDa. Activin Receptor Type IA is widely expressed in various tissues including skeletal muscle heart and central nervous system. It functions through the binding of ligands like activins and bone morphogenetic proteins (BMPs) which triggers intracellular signaling cascades important for cellular processes.

Biological function summary

Activin Receptor Type IA plays a significant role in several cellular activities including growth and differentiation. It operates as part of a receptor complex with type II receptors like ACVR2A protein which facilitates ligand binding and phosphorylation. Activin receptor is essential for the regulation of mesoderm induction and organ development notably in the skeletal and muscular systems. Its interaction with activin protein family members influences various developmental processes.

Pathways

Activin Receptor Type IA is an integral component of the TGF-beta signaling pathway and BMP pathway. These pathways are vital for embryonic development and tissue homeostasis. Activin receptor interacts with the SMAD family of proteins which mediate signal transduction to the nucleus influencing gene expression. Through these pathways it relates functionally to SMAD1 and SMAD2 proteins that contribute to cell proliferation and differentiation dynamics.

Activin Receptor Type IA is associated with fibrodysplasia ossificans progressiva (FOP) and cancer. Mutations in the ACVR1 gene can lead to abnormal bone growth seen in FOP commonly due to erroneous activation of the BMP signaling pathway. In some cancers the dysregulation of activin receptor signaling can alter cell proliferation rates placing it in connection with proteins involved in oncogenic processes. Targeting activin receptor pathways might offer therapeutic potential in certain diseases by modulating or restoring its normal signaling capability.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed : 20628059, PubMed : 22977237). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed : 17911401). Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain (PubMed : 25354296). In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal (PubMed : 9748228). In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (PubMed : 17911401). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity).

See full target information ACVR1

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文献 (10)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2036 PubMed40021625

2025

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

Applications

Unspecified application

Species

Unspecified reactive species

Min Pan,Yinwen Zhang,William C Wright,Xueying Liu,Barbara Passaia,Duane Currier,Jonathan Low,Richard H Chapple,Jacob A Steele,Jon P Connelly,Bensheng Ju,Emily Plyler,Meifen Lu,Allister J Loughran,Lei Yang,Brian J Abraham,Shondra M Pruett-Miller,Burgess Freeman,George E Campbell,Michael A Dyer,Taosheng Chen,Elizabeth Stewart,Selene Koo,Heather Sheppard,John Easton,Paul Geeleher

Gut microbes 17:2463581 PubMed39924917

2025

infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Xinbo Xu,Xiao Fei,Huan Wang,Xidong Wu,Yuan Zhan,Xin Li,Yan'an Zhou,Chunxi Shu,Cong He,Yi Hu,Jianping Liu,Nonghua Lv,Nianshuang Li,Yin Zhu

American journal of cancer research 13:1471-1485 PubMed37168326

2023

Somatic-to-primordial germ cell-like transformation is critical in tumor initiation of mouse breast tumor 4T1 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhan Ma,Fengyu Zhang,Aiping Liu,Huikuan Lin,Chunfang Liu

CNS neuroscience & therapeutics 29:1405-1422 PubMed36756722

2023

Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Huiqing Hou,Yafei Wang,Lan Yang,Yongjun Wang

Nutrients 14: PubMed35956351

2022

Glycochenodeoxycholate Affects Iron Homeostasis via Up-Regulating Hepcidin Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Long-Jiao Wang,Guo-Ping Zhao,Xi-Fan Wang,Xiao-Xue Liu,Yi-Xuan Li,Li-Li Qiu,Xiao-Yu Wang,Fa-Zheng Ren

The Journal of clinical investigation 132: PubMed35511419

2022

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.

Applications

Unspecified application

Species

Unspecified reactive species

Senem Aykul,Lily Huang,Lili Wang,Nanditha M Das,Sandra Reisman,Yonaton Ray,Qian Zhang,Nyanza Rothman,Kalyan C Nannuru,Vishal Kamat,Susannah Brydges,Luca Troncone,Laura Johnsen,Paul B Yu,Sergio Fazio,John Lees-Shepard,Kevin Schutz,Andrew J Murphy,Aris N Economides,Vincent Idone,Sarah J Hatsell

Biochemical and biophysical research communication 528:299-304 PubMed32473755

2020

Involvement of activin a receptor type 1 (ACVR1) in the pathogenesis of primary focal hyperhidrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Bo Lin,Jian-Feng Chen,Fan-Cai Lai,Xu Li,Jin-Bao Xie,Yuan-Rong Tu,Ming-Qiang Kang

Cells 8: PubMed31779280

2019

Expression of miRNAs from the Imprinted Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Laetitia Barrault,Jacqueline Gide,Tingting Qing,Lea Lesueur,Jorg Tost,Jerome Alexandre Denis,Michel Cailleret,Laetitia Aubry,Marc Peschanski,Cécile Martinat,Sandrine Baghdoyan

Journal of experimental & clinical cancer research 38:107 PubMed30819221

2019

Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xu-Bo Wu,Xia Feng,Qi-Meng Chang,Cheng-Wu Zhang,Zhi-Fei Wang,Jie Liu,Zhi-Qiu Hu,Jia-Zhe Liu,Wei-Ding Wu,Zi-Ping Zhang,Xi-Qiang Liu

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 30:733-41 PubMed25413979

2014

The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.

Applications

Unspecified application

Species

Unspecified reactive species

Diana Rigueur,Sean Brugger,Teni Anbarchian,Jong Kil Kim,YooJin Lee,Karen M Lyons

View all publications

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重组Anti-Activin Receptor Type IA抗体[EPR4076(2)]