重组Anti-Activin A Receptor Type IB/ALK-4抗体[S08-8D6] (ab317379)
![Western blot - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379)](https://www.abcam.cn/ps/products/317/ab317379/Images/ab317379-536473-anti-activin-a-receptor-type-ibalk4-antibody-s08-8d6-western-blot-chok1-brain-chinese-hamster-rat.jpg "Western blot - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [S08-8D6] to Activin A Receptor Type IB/ALK-4
- Suitable for: ICC/IF, WB
- Reacts with: Rat, Human, Chinese hamster
概述
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产品名称
Anti-Activin A Receptor Type IB/ALK-4抗体[S08-8D6]
参阅全部 Activin A Receptor Type IB/ALK-4 一抗 -
描述
兔单克隆抗体[S08-8D6] to Activin A Receptor Type IB/ALK-4 -
宿主
Rabbit -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Rat, Human, Chinese hamster -
免疫原
Synthetic peptide corresponding to Human Activin A Receptor Type IB/ALK-4.
Database link: P36896 -
阳性对照
- WB: CHO-K1 cell lysate. Rat brain lysate. ICC/IF: HeLa cells.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA -
Concentration information loading... -
纯度
Affinity purified -
克隆
单克隆 -
克隆编号
S08-8D6 -
同种型
IgG -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab317379于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
1/20 - 1/50.
|
|
| WB |
1/1000 - 1/5000. Predicted molecular weight: 57 kDa.
|
| 说明 |
|---|
|
ICC/IF
1/20 - 1/50. |
|
WB
1/1000 - 1/5000. Predicted molecular weight: 57 kDa. |
靶标
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功能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2. -
组织特异性
Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. -
序列相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
翻译后修饰
Autophosphorylated. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 91 Human
- Entrez Gene: 29381 Rat
- Omim: 601300 Human
- SwissProt: P36896 Human
- SwissProt: P80202 Rat
- Unigene: 438918 Human
- Unigene: 214018 Rat
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形式
There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3. -
别名
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
see all
图片
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Western blot - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379)All lanes : Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379) at 1/500 dilution
Lane 1 : CHO-K1 cell lysate
Lane 2 : Rat brain lysate
Predicted band size: 57 kDa -
![Immunocytochemistry/ Immunofluorescence - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379)](https://www.abcam.cn/ps/products/317/ab317379/Images/ab317379-536474-anti-activin-a-receptor-type-ibalk4-antibody-s08-8d6-immunocytochemistry-hela-human.jpg)
Immunocytochemistry/ Immunofluorescence - Anti-Activin A Receptor Type IB/ALK-4 Antibody [S08-8D6] (ab317379)Immunofluorescence of Activin A Receptor Type IB/ALK-4 (green) in HeLa using ab317379 at dilution 1/50, and DAPI (blue).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab317379 尚未被引用在任何文献中。