AB156576

Anti-ACOT7 抗体 [EPR11317(B)]

Anti-ACOT7 antibody [EPR11317(B)]

RabMAb
Recombinant
了解详情

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(2 Publications)

Rabbit Recombinant Monoclonal ACOT7 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications.

查看别名

BACH, ACOT7, Cytosolic acyl coenzyme A thioester hydrolase, Acyl-CoA thioesterase 7, Brain acyl-CoA hydrolase, CTE-IIa, Long chain acyl-CoA thioester hydrolase, hBACH, CTE-II

2 Images

Unknown

Immunoprecipitation - Anti-ACOT7 antibody [EPR11317(B)] (AB156576)

WB analysis of immunoprecipites
ab156576, at a 1/1000 dilution, staining ACOT7 in Jurkat cell lysate immunoprecipitated using ab156576 at 1/100 dilution.

All lanes:

Immunoprecipitation - Anti-ACOT7 antibody [EPR11317(B)] (ab156576)

Predicted band size: 42 kDa

false

Unknown

Western blot - Anti-ACOT7 antibody [EPR11317(B)] (AB156576)

All lanes:

Western blot - Anti-ACOT7 antibody [EPR11317(B)] (ab156576) at 1/1000 dilution

Lane 1:

fetal brain cell lysate at 10 µg/mL

Lane 2:

A375 cell lysate at 10 µg/mL

Lane 3:

293T cell lysate at 10 µg/mL

Lane 4:

Jurkat cell lysate at 10 µg/mL

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 42 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-ACOT7 antibody [EPR11317(B)] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11317(B)

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IP

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/100 - 1/500", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ACOT7 also known as cytosolic acyl-CoA thioesterase 7 plays an important role in lipid metabolism by hydrolyzing acyl-CoA thioesters into free fatty acids and CoA. This enzyme possesses a molecular mass of approximately 44 kilodaltons. ACOT7 primarily expresses in the brain with significant levels in neurons. This distribution suggests involvement in processes related to brain lipid metabolism and energy homeostasis.

Biological function summary

ACOT7 influences the regulation of lipid pools and fatty acid signaling in neural cells. It participates in the modulation of free fatty acid concentrations affecting energy metabolism and neuronal function. While ACOT7 does not typically associate with larger protein complexes its enzymatic action impacts the availability and signaling of lipid molecules within the cell potentially influencing cellular responses and energy dynamics.

Pathways

ACOT7 plays a role in fatty acid metabolism and energy homeostasis pathways. It connects with lipid metabolism processes involving enzymes like fatty acid synthase and acyl-CoA synthetase enzymes. By modulating the levels of acyl-CoA and free fatty acids ACOT7 affects broader metabolic pathways that control cellular energy balance and lipid synthesis in brain tissues.

ACOT7 links to neurological conditions and energy metabolism disorders. Its alteration associates with neurodegenerative diseases such as Alzheimer's disease due to its role in maintaining neuronal lipid balance. Furthermore conditions like metabolic syndrome may relate to changes in ACOT7 function given its impact on lipid metabolism. Proteins like amyloid-beta precursor protein in Alzheimer's disease have connections to ACOT7 through these metabolic processes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed : 10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed : 10578051). May play an important physiological function in brain (PubMed : 10578051).

See full target information ACOT7

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Pharmaceuticals (Basel, Switzerland) 17: PubMed39338366

2024

Intermedin Alleviates Diabetic Cardiomyopathy by Up-Regulating CPT-1β through Activation of the Phosphatidyl Inositol 3 Kinase/Protein Kinase B Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zhao,Ling Han,Ya-Rong Zhang,Shi-Meng Liu,Deng-Ren Ji,Rui Wang,Yan-Rong Yu,Mo-Zhi Jia,San-Bao Chai,Hui-Fang Tang,Wei Huang,Yong-Fen Qi

Cell death & disease 15:573 PubMed39117605

2024

Elucidating the role of S100A10 in CD8 T cell exhaustion and HCC immune escape via the cPLA2 and 5-LOX axis.

Applications

Unspecified application

Species

Unspecified reactive species

Ganggang Wang,Xiaowei Shen,Wenzhi Jin,Chao Song,Meiyuan Dong,Zhijie Zhou,Xiaoliang Wang

View all publications

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Abcam Product Promise

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Anti-ACOT7 抗体 [EPR11317(B)]