Anti-ACE2抗体(ab272690)
Key features and details
- Rabbit polyclonal to ACE2
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ACE2抗体
参阅全部 ACE2 一抗 -
描述
兔多克隆抗体to ACE2 -
宿主
Rabbit -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human ACE2 aa 550-650 conjugated to keyhole limpet haemocyanin.
Database link: Q9BYF1 -
阳性对照
- Flow Cyt: HepG2 cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab272690于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
1/50.
|
| 说明 |
|---|
|
Flow Cyt
1/50. |
靶标
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功能
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. -
组织特异性
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. -
序列相似性
Belongs to the peptidase M2 family. -
翻译后修饰
N-glycosylation on Asn-90 may limit SARS infectivity. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 59272 Human
- Omim: 300335 Human
- SwissProt: Q9BYF1 Human
- Unigene: 178098 Human
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别名
- ACE 2 antibody
- ACE related carboxypeptidase antibody
- ACE-related carboxypeptidase antibody
see all
图片
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Flow Cytometry - Anti-ACE2 antibody (ab272690)
Flow cytometry analysis of HepG2 human cells labelled for ACE2 using ab272690 at 1/50 dilution. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green) and isotype control (orange).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab272690 被引用在 5 文献中.
- Basile A et al. Spike-mediated viral membrane fusion is inhibited by a specific anti-IFITM2 monoclonal antibody. Antiviral Res 211:105546 (2023). PubMed: 36669656
- Emslander Q et al. MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake. Viruses 15:N/A (2023). PubMed: 37632105
- Park GC et al. ACE2 and TMPRSS2 Immunolocalization and COVID-19-Related Thyroid Disorder. Biology (Basel) 11:N/A (2022). PubMed: 35625425
- Park GC et al. ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19. Oral Dis 28 Suppl 2:2456-2464 (2022). PubMed: 35000261
- Bouwman KM et al. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins. PLoS Pathog 17:e1009282 (2021). PubMed: 33556147