Anti-ACD抗体(ab112050)
Key features and details
- Rabbit polyclonal to ACD
- Suitable for: WB, IP
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ACD抗体
参阅全部 ACD 一抗 -
描述
兔多克隆抗体to ACD -
宿主
Rabbit -
经测试应用
适用于: WB, IPmore details -
种属反应性
与反应: Human
预测可用于: Rat, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
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免疫原
Synthetic peptide corresponding to Human ACD aa 150-200. (GeneID 65057)
Database link: NP_001075955.1 -
阳性对照
- HeLa and Jurkat whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab112050于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/2000 - 1/10000. Predicted molecular weight: 58 kDa.
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| IP |
Use at 2-5 µg/mg of lysate.
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| 说明 |
|---|
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WB
1/2000 - 1/10000. Predicted molecular weight: 58 kDa. |
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IP
Use at 2-5 µg/mg of lysate. |
靶标
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功能
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. -
细胞定位
Nucleus. Chromosome > telomere. - Information by UniProt
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数据库链接
- Entrez Gene: 65057 Human
- Entrez Gene: 307798 Rat
- Omim: 609377 Human
- SwissProt: Q96AP0 Human
- SwissProt: Q4FZR5 Rat
- Unigene: 78019 Human
- Unigene: 8611 Rat
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别名
- Acd antibody
- ACD_HUMAN antibody
- Adrenocortical dysplasia homolog antibody
see all
图片
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Western blot - Anti-ACD antibody (ab112050)All lanes : Anti-ACD antibody (ab112050) at 0.4 µg/ml
Lane 1 : Jurkat whole cell lysate at 50 µg
Lane 2 : Jurkat whole cell lysate at 15 µg
Lane 3 : Jurkat whole cell lysate at 5 µg
Lane 4 : HeLa whole cell lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 58 kDa
Exposure time: 3 minutes -
Immunoprecipitation - Anti-ACD antibody (ab112050)ab112050 at 1 µg/ml staining PDE3A in HeLa cell lysate immunoprecipitated using ab112050 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: controle IgG. Predicted band size : 58 kDa Exposure time: 30 seconds
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab112050 被引用在 1 文献中.
- Smith EW et al. Insights into POT1 structural dynamics revealed by cryo-EM. PLoS One 17:e0264073 (2022). PubMed: 35176105