Anti-ACADL/LCAD抗体(ab129711)
Key features and details
- Rabbit polyclonal to ACADL/LCAD
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-ACADL/LCAD抗体
参阅全部 ACADL/LCAD 一抗 -
描述
兔多克隆抗体to ACADL/LCAD -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide corresponding to Human ACADL/LCAD.
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阳性对照
- Rat kidney tissue lysate, Mouse 3T3 cell lysate and Jurkat whole cell lysate (ab7899)
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 3139 ACADL Antibody. 3139-100 is the same size as the 100 µg size of ab129711.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 69% PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.15% EDTA -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129711于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 47 kDa.
|
| 说明 |
|---|
|
WB
Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 47 kDa. |
靶标
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通路
Lipid metabolism; mitochondrial fatty acid beta-oxidation. -
疾病相关
Defects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD) [MIM:201475]. An inborn error of mitochondrial fatty acid beta-oxidation which leads to impaired long-chain fatty acid beta-oxidation. It is clinically heterogeneous, with three major phenotypes: a severe childhood form characterized by early onset, high mortality and high incidence of cardiomyopathy; a milder childhood form with later onset, characterized by hypoketotic hypoglycemia, low mortality and rare cardiomyopathy; an adult form, with isolated skeletal muscle involvement, rhabdomyolysis and myoglobinuria, usually triggered by exercise or fasting. -
序列相似性
Belongs to the acyl-CoA dehydrogenase family. -
细胞定位
Mitochondrion matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 33 Human
- Entrez Gene: 11363 Mouse
- Entrez Gene: 25287 Rat
- Omim: 609576 Human
- SwissProt: P28330 Human
- SwissProt: P51174 Mouse
- SwissProt: P15650 Rat
- Unigene: 471277 Human
see all -
别名
- ACAD4 antibody
- ACADL antibody
- ACADL_HUMAN antibody
see all
图片
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Western blot - Anti-ACADL/LCAD antibody (ab129711)All lanes : Anti-ACADL/LCAD antibody (ab129711) at 4 µg/ml
Lane 1 : Rat
kidney tissue lysate
Lane 2 : Mouse 3T3
cell lysate
Lanes 3-4 : Jurkat cell lysate
Predicted band size: 47 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab129711 被引用在 11 文献中.
- Yau WW et al. Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency. Hum Mol Genet 32:1922-1931 (2023). PubMed: 36881658
- Wang C et al. The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice. Nat Commun 14:959 (2023). PubMed: 36810848
- Yu Y et al. Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway. Front Cardiovasc Med 9:803510 (2022). PubMed: 35282369
- Saed CT et al. The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes. Can J Physiol Pharmacol 100:393-401 (2022). PubMed: 34851748
- Gopal K et al. FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity. Cell Rep 35:108935 (2021). PubMed: 33826891