AB198697

Anti-ABIN3抗体

Name: ABIN3抗体 (ab198697)| Abcam中文官网
Brand: Abcam Limited
SKU: AB198697
Price: 4973 CNY
Availability: InStock

Anti-ABIN3 antibody

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(2 Publications)

Rabbit Polyclonal ABIN3 antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TNIP3.

查看别名

ABIN3, LIND, TNIP3, TNFAIP3-interacting protein 3, A20-binding inhibitor of NF-kappa-B activation 3, Listeria-induced gene protein, ABIN-3

1 Images

Supplier Data

Western blot - Anti-ABIN3 antibody (AB198697)

All lanes:

Western blot - Anti-ABIN3 antibody (ab198697) at 1/200 dilution

All lanes:

mouse brain tissue lysate at 40 µg

Predicted band size: 39 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

applications

免疫原

Synthetic Peptide within Human TNIP3. The exact immunogen used to generate this antibody is proprietary information.

Q96KP6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ABIN3 also known as TNIP3 is a protein with a molecular mass of approximately 68 kDa. It is widely expressed in various tissues notably in the immune system. ABIN3 acts as an important mediator in modulating cellular responses to external stress signals. It interacts with several signaling pathways modulating functions at the cellular level. ABIN3's action significantly regulates immune responses by binding to and inhibiting specific proteins involved in inflammation.

Biological function summary

ABIN3 regulates immune response and participates in controlling inflammation. It acts together with other components to form signaling complexes. This complex assembly plays a role in dampening excessive inflammatory signals. By regulating components of innate immune responses ABIN3 helps maintain immune homeostasis. Its interaction is significant in controlling the overall activity within signaling hubs that manage inflammation.

Pathways

ABIN3 involves itself in critical inflammatory pathways such as the NF-κB pathway. This protein modulates NF-κB activation by hindering its activity ensuring proper balance in immune signaling. ABIN3 connects with proteins like A20 acting together to prevent overactivation that could lead to inflammation. Such modulation is central in managing cellular defenses and preventing inappropriate tissue damage.

Researchers link ABIN3 to conditions like inflammatory bowel disease (IBD) and rheumatoid arthritis. In these diseases ABIN3's role in moderating immune response becomes relevant as dysfunctions here can lead to excessive inflammation. ABIN3 works in concert with proteins like TNFα where an imbalance may result in chronic inflammatory states characteristic of these diseases. Understanding these interactions offers potential therapeutic avenues in treating inflammatory disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

See full target information TNIP3

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 12:589 PubMed34103479

2021

Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution.

Applications

Unspecified application

Species

Unspecified reactive species

Linhe Wang,Jie Li,Shuai He,Yang Liu,Haitian Chen,Shujiao He,Meixian Yin,Dawei Zou,Shirui Chen,Tao Luo,Xinyu Yu,Xuesi Wan,Shunwei Huang,Zhiyong Guo,Xiaoshun He

OncoTargets and therapy 12:5003-5012 PubMed31303760

2019

ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Yehua Shen,Gang Chen,Liping Zhuang,Litao Xu,Junhua Lin,Luming Liu

View all publications

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Anti-ABIN3抗体

Anti-ABIN3 antibody

Western blot - Anti-ABIN3 antibody (AB198697)