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AB97383

Anti-ABCD2抗体

Anti-ABCD2 antibody

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(1 Publication)

Rabbit Polyclonal ABCD2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ABCD2 aa 300-600.

查看别名

ALD1, ALDL1, ALDR, ALDRP, ABCD2, ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR

1 Images
Western blot - Anti-ABCD2 antibody (AB97383)
  • WB

Unknown

Western blot - Anti-ABCD2 antibody (AB97383)

7.5% SDS PAGE

All lanes:

Western blot - Anti-ABCD2 antibody (ab97383) at 1/1000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 83 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human ABCD2 aa 300-600. The exact immunogen used to generate this antibody is proprietary information.

Q9UBJ2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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产品详情

Post translation modification - Glycoprotein
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The ABCD2 protein also known as ALDR (adrenoleukodystrophy-related protein) is a member of the ATP-binding cassette (ABC) transporter family located on the peroxisomal membrane. It plays a role in the transport of very-long-chain fatty acids (VLCFAs) into peroxisomes. The molecular mass of ABCD2 is approximately 80 kDa. Expression of ABCD2 occurs widely in tissues with high levels found in adrenal glands brain and liver.
Biological function summary

ABCD2 influences the metabolism of lipids within cells by facilitating the import of VLCFAs which are subsequently broken down through beta-oxidation inside peroxisomes. It operates as part of a peroxisomal beta-oxidation complex. This protein also shares functional similarities with other ABC family transporters such as ABCD1 though with slightly different substrate specificities. Expression of ABCD2 increases in response to certain dietary and hormonal factors indicating a role in metabolic adaptation.

Pathways

ABCD2 integrates into peroxisomal fatty acid beta-oxidation and lipid metabolism pathways. It associates closely with ABCD1 within these pathways contributing to the regulation of fatty acid levels in cells. A deficiency in ABCD2 affects these metabolic pathways by altering VLCFA transport and utilization leading to an imbalance with downstream metabolic effects. The protein also interacts with PPAR (peroxisome proliferator-activated receptors) signaling influencing lipid homeostasis.

Issues with ABCD2 are linked to adrenoleukodystrophy (ALD) an inherited disorder that affects the nervous system and adrenal glands due to the accumulation of VLCFAs. The disease connects ABCD2 and ABCD1 proteins since mutations in the ABCD1 gene are known to cause ALD. Researchers are interested in ABCD2's potential compensatory role in similar metabolic pathways possibly offering therapeutic implications. Recent studies also explore connections between ABCD2 dysregulation and liver disorders involving VLCFA metabolism but further research is necessary to establish these links conclusively.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed : 21145416, PubMed : 29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed : 29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22 : 0) and polyunsaturated fatty acid (PUFA) such as C22 : 6-CoA and C24 : 6-CoA (in vitro) (PubMed : 21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed : 21145416).
See full target information ABCD2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal and liver diseases : JGLD 25:39-48 PubMed27014752

2016

Altered Expression of Angiotensinogen and Mediators of Angiogenesis in Ileal Crohn's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Georgia E Hume,James D Doecke,Ning Huang,Elizabeth V Fowler,Ian S Brown,Lisa A Simms,Graham L Radford-Smith
View all publications
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