重组Anti-5HT7 Receptor抗体[EPR6271] (ab128892)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR6271] to 5HT7 Receptor
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-5HT7 Receptor抗体[EPR6271]
参阅全部 5HT7 Receptor 一抗 -
描述
兔单克隆抗体[EPR6271] to 5HT7 Receptor -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide within Human 5HT7 Receptor (extracellular). The exact sequence is proprietary.
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阳性对照
- U-87MG, SK-OV-3, and Caco 2 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
解离常数(KD)
KD = 8.10 x 10 -12 M Learn more about KD -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR6271 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128892于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 54 kDa.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 54 kDa. |
靶标
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功能
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. -
组织特异性
Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3363 Human
- Entrez Gene: 15566 Mouse
- Entrez Gene: 65032 Rat
- Omim: 182137 Human
- SwissProt: P34969 Human
- SwissProt: P32304 Mouse
- SwissProt: P32305 Rat
- Unigene: 73739 Human
see all -
别名
- 5 HT 7 antibody
- 5 HT X antibody
- 5 hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase coupled) antibody
see all
图片
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All lanes : Anti-5HT7 Receptor antibody [EPR6271] (ab128892) at 1/1000 dilution
Lane 1 : U-87 MG cell lysate
Lane 2 : SK-OV-3 cell lysate
Lane 3 : Caco 2 cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP-conjugated goat anti-rabbit at 1/2000 dilution
Predicted band size: 54 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab128892 被引用在 6 文献中.
- Rodnyy AY et al. Serotonin 5-HT7 receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice. J Neurosci Res 100:1506-1523 (2022). PubMed: 35443076
- Zhan TT et al. Tandospirone prevents stress-induced anxiety-like behavior and visceral hypersensitivity by suppressing theta oscillation enhancement via 5-HT1A receptors in the anterior cingulate cortex in rats. Front Cell Neurosci 16:922750 (2022). PubMed: 36072567
- Liu L et al. Determining 5HT7R's Involvement in Modifying the Antihyperalgesic Effects of Electroacupuncture on Rats With Recurrent Migraine. Front Neurosci 15:668616 (2021). PubMed: 34163324
- Kondaurova EM et al. Genetic Background Underlying 5-HT1A Receptor Functioning Affects the Response to Fluoxetine. Int J Mol Sci 21:N/A (2020). PubMed: 33233644
- Demireva EY et al. Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research. Physiol Genomics 51:290-301 (2019). PubMed: 31125290
- Ni J et al. The serotonin (5-hydroxytryptamine) 5-HT7 receptor is up-regulated in Onuf's nucleus in rats with chronic spinal cord injury. BJU Int 123:718-725 (2019). PubMed: 29781566