AB216959

Anti-5HT2A Receptor抗体

Name: 5HT2A Receptor抗体 (ab216959)| Abcam中文官网
Brand: Abcam Limited
SKU: AB216959
Price: 4990 CNY
Availability: InStock

Anti-5HT2A Receptor antibody

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(9 Publications)

Rabbit Polyclonal 5HT2A Receptor antibody. Suitable for WB and reacts with Rat samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human HTR2A aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

查看别名

HTR2, HTR2A, 5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A

1 Images

Supplier Data

Western blot - Anti-5HT2A Receptor antibody (AB216959)

All lanes:

Western blot - Anti-5HT2A Receptor antibody (ab216959) at 1/1000 dilution

Lane 1:

Mouse cerebrum lysates

Lane 2:

Rat cerebrum lysate

Secondary

All lanes:

Conjugated Secondary at 1/20000 dilution

Predicted band size: 53 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Synthetic Peptide within Human HTR2A aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P28223

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The 5HT2A receptor also known as 5-hydroxytryptamine receptor 2A is a G-protein coupled receptor with a molecular mass of approximately 52 kDa. It is one of the key receptors for serotonin (5-HT) and is chiefly expressed in the central nervous system including regions like the cortex and the basal ganglia. This receptor binds serotonin and initiates a cascade of intracellular events which can alter neuronal activity and influence various neuropsychological functions.

Biological function summary

The 5HT2A receptor modulates cognitive functions such as learning and memory and it also plays a role in mood regulation. This receptor is involved in a complex of signaling pathways and interacts with other receptors such as the 5HT1A receptor and proteins like phospholipase C in downstream signaling. Through these interactions the receptor contributes to maintaining a balance in neurotransmitter systems.

Pathways

This receptor is actively involved in the serotonergic signaling pathway. It participates by interacting with the phosphatidylinositol signaling system affecting intracellular calcium levels. The 5HT2A receptor works alongside other proteins such as the dopamine D2 receptor forming a link between serotonin and dopamine pathways which are integral to mood and behavior regulation.

The 5HT2A receptor is closely linked to schizophrenia and depression. Alterations in the receptor's function or expression levels have been associated with the pathophysiology of these disorders. The receptor's interactions with other proteins including the 5HT1A receptor have been implicated in the therapeutic mechanisms of antipsychotic and antidepressant medications highlighting its significance in mental health treatment strategies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed : 1330647, PubMed : 18703043, PubMed : 19057895, PubMed : 21645528, PubMed : 22300836, PubMed : 35084960, PubMed : 38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed : 28129538, PubMed : 35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed : 28129538, PubMed : 35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed : 18703043, PubMed : 28129538, PubMed : 35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed : 28129538, PubMed : 35084960). Affects neural activity, perception, cognition and mood (PubMed : 18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.

See full target information HTR2A

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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Pharmacology research & perspectives 13:e70079 PubMed39996441

2025

Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ- and MES-Induced Seizures in Mice via 5-HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad Balabandian,Mohammad Amin Manavi,Ali Lesani,Razieh Mohammad Jafari,Hamed Shafaroodi,Navid Heidari,Javad Mirnajafi-Zadeh,Alireza Foroumadi,Arya Afrooghe,Ahmad Reza Dehpour

Heliyon 10:e33050 PubMed38994087

2024

"Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)".

Applications

Unspecified application

Species

Unspecified reactive species

Zahra Ebrahim Soltani,Mohammad Elahi,Maziyar Askari Rad,Sara Farsio,Ahmad Reza Dehpour

International journal of molecular sciences 25: PubMed38203271

2024

Limbic System Response to Psilocybin and Ketamine Administration in Rats: A Neurochemical and Behavioral Study.

Applications

Unspecified application

Species

Unspecified reactive species

Adam Wojtas,Agnieszka Bysiek,Agnieszka Wawrzczak-Bargiela,Marzena Maćkowiak,Krystyna Gołembiowska

Psychopharmacology 241:33-47 PubMed37682294

2023

Trait sensitivity to positive feedback is a predisposing factor for several aspects of compulsive alcohol drinking in male rats: behavioural, physiological, and molecular correlates.

Applications

Unspecified application

Species

Unspecified reactive species

Agata Cieslik-Starkiewicz,Karolina Noworyta,Joanna Solich,Agata Korlatowicz,Agata Faron-Górecka,Rafal Rygula

Cell death discovery 8:290 PubMed35710537

2022

microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting DNMT1.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiguo Wu,Jian Tan,Lichang Lin,Wenting Zhang,Wanqiu Yuan

Frontiers in neuroscience 16:863793 PubMed35573286

2022

The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zuliyaer Talifu,Chuan Qin,Zhang Xin,Yixin Chen,Jiayi Liu,Subarna Dangol,Xiaodong Ma,Han Gong,Zhisheng Pei,Yan Yu,Jianjun Li,Liangjie Du

Frontiers in psychiatry 12:645081 PubMed33776821

2021

Expression of Dopamine D and Serotonin 5-HT Receptors in Blood Mononuclear Cells in Schizophrenia.

Applications

Unspecified application

Species

Unspecified reactive species

Adam Wysokiński,Elżbieta Kozłowska,Ewa Szczepocka,Anna Łucka,Justyna Agier,Ewa Brzezińska-Błaszczyk,Katarzyna Sobierajska

Journal of pain research 13:2113-2124 PubMed32903807

2020

Long Noncoding RNA H19 Induces Neuropathic Pain by Upregulating Cyclin-Dependent Kinase 5-Mediated Phosphorylation of cAMP Response Element Binding Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Li,Yuan Jiao,Xuli Ren,Di You,Rangjuan Cao

Drug research 69:352-360 PubMed30536257

2018

Evaluation of Isolated Vascular Response to 5HT1A, 5HT1B1D & 5HT2A Receptors Agonist & Antagonist in Chronic Endotoxemic Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Razieh Afshar Moghaddam,Farahnaz Jazaeri,Alireza Abdollahi,Razieh Mohammadjafari,Ahmad Reza Dehpour,Azam Bakhtiarian

View all publications

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Anti-5HT2A Receptor抗体

Anti-5HT2A Receptor antibody

Western blot - Anti-5HT2A Receptor antibody (AB216959)