Anti-5-HT2C Receptor抗体(ab32887)
Key features and details
- Goat polyclonal to 5-HT2C Receptor
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-5-HT2C Receptor抗体
参阅全部 5-HT2C Receptor 一抗 -
描述
山羊多克隆抗体to 5-HT2C Receptor -
宿主
Goat -
特异性
Ab32887 recognises 5HT2C Receptor. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Dog, Chimpanzee -
免疫原
Synthetic peptide:
C-QVENLELPVN
, corresponding to amino acids 437-446 of Human 5HT2C Receptor. -
阳性对照
- Lysates of EBV immortalised Lymphoblastoids, T cell, MOLT4 and monocytic cell line U937.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Ab32887 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab32887于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa).
1 hour primary incubation is recommended for this product. |
说明 |
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WB
Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 52 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
结构域
The PDZ domain-binding motif is involved in the interaction with MPDZ. -
翻译后修饰
N-glycosylated. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 473740 Chimpanzee
- Entrez Gene: 450240 Dog
- Entrez Gene: 3358 Human
- Entrez Gene: 15560 Mouse
- Entrez Gene: 25187 Rat
- Omim: 312861 Human
- SwissProt: Q5IS66 Chimpanzee
- SwissProt: Q60F97 Dog
see all -
别名
- 5 Hydroxytryptamine 2C receptor antibody
- 5-HT-1C antibody
- 5-ht-1c receptor antibody
see all
图片
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Anti-5-HT2C Receptor antibody (ab32887) at 1 µg/ml + EBV immortalised Lymphoblastoid lysate in RIPA buffer at 35 µg
Developed using the ECL technique.
Predicted band size: 52 kDa
Observed band size: 50 kDa why is the actual band size different from the predicted?
Exposure time: 1 minute
数据表及文件
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Datasheet download
文献 (3)
ab32887 被引用在 3 文献中.
- Price AE et al. Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex. ACS Chem Neurosci 10:3241-3248 (2019). PubMed: 30645940
- Delicata F et al. Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence. CNS Neurosci Ther 24:721-733 (2018). PubMed: 29479825
- Ji G et al. 5-HT2CReceptor Knockdown in the Amygdala Inhibits Neuropathic-Pain-Related Plasticity and Behaviors. J Neurosci 37:1378-1393 (2017). PubMed: 28011743