AB244205

重组Anti-15 Lipoxygenase 1抗体[EPR22138]

Anti-15 Lipoxygenase 1 antibody [EPR22138]

BOND RX™ Validated
RabMAb
Recombinant
KO Validated
了解详情

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(32 Publications)

Anti-15 Lipoxygenase 1 antibody [EPR22138] (ab244205) is a rabbit monoclonal antibody detecting 15 Lipoxygenase 1 in Western Blot, IHC-P, IHC-Fr, ICC/IF. Suitable for Human, Mouse, Rat.

- KO validated for confirmed specificity
- Biophysical QC for unrivalled batch-batch consistency
- Over 10 publications

查看别名

LOG15, ALOX15, Polyunsaturated fatty acid lipoxygenase ALOX15, 12/15-lipoxygenase, Arachidonate 15-lipoxygenase, Arachidonate omega-6 lipoxygenase, Hepoxilin A3 synthase Alox15, Linoleate 13S-lipoxygenase, 12-LOX, 15-LOX, 15-LOX-1

12 Images

Immunocytochemistry/ Immunofluorescence - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

ICC/IF

Lab

Immunocytochemistry/ Immunofluorescence - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized MCF7 (human breast adenocarcinoma epithelial cell) cells labelling 15 Lipoxygenase 1 with primary antibody anti-15 Lipoxygenase 1 (ab244205) at 1/50 dilution, followed by Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) secondary antibody at 1/1000 dilution. Confocal image showing cytoplasmic staining in MCF7 cells. Anti-alpha Tubulin antibody (DM1A) - Microtubule Marker (Alexa Fluor® 594) (ab195889) was used to counterstain tubulin at 1/200 dilution. The nuclear counter stain is DAPI (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemical analysis of paraffin-embedded human colon tissue labeling 15 Lipoxygenase 1 with ab244205 at 1/4000 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Positive staining in eosinophils of human colon (PMID : 30118527; PMID : 23503644). Counter stained with hematoxylin. Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer pH 9.0).

Secondary antibody only control : Used PBS instead of primary antibody secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemical analysis of paraffin-embedded human bronchus tissue labeling 15 Lipoxygenase 1 with ab244205 at 1/4000 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Positive staining in epithelial cells of human bronchus (PMID : 24036245; PMID : 21831839). Counter stained with hematoxylin. Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer pH 9.0).

Secondary antibody only control : Used PBS instead of primary antibody secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemical analysis of paraffin-embedded rat bronchus tissue labeling 15 Lipoxygenase 1 with ab244205 at 1/4000 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Positive staining in epithelial cells of rat bronchus (PMID : 24036245; PMID : 21831839). Counter stained with hematoxylin. Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer pH 9.0).

Secondary antibody only control : Used PBS instead of primary antibody secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

ICC/IF

Lab

Immunocytochemistry/ Immunofluorescence - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized PC-12 (rat adrenal gland pheochromocytoma small irregularly shaped cells) cells labelling 15 Lipoxygenase 1 with primary antibody anti-15 Lipoxygenase 1 (ab244205) at 1/50 dilution, followed by Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) secondary antibody at 1/1000 dilution. Confocal image showing cytoplasmic staining in PC-12 cells. Anti-alpha Tubulin antibody (DM1A) - Microtubule Marker (Alexa Fluor® 594) (ab195889) was used to counterstain tubulin at 1/200 dilution. The nuclear counter stain is DAPI (blue).

AbReview79622****

Immunocytochemistry - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunocytochemistry analysis of formaldehyde-fixed 0.1% triton x100 permeabilized mouse macrophage cells staining with ab244205 at 1/200 dilution. Secondary antibody was Alexa Fluor™ 594 Anti-Rb at 1/500 dilution. Samples were incubated with the primary antibody for 1 hour at 25°C. Blocking was done using 5% BSA for 1 hour at 25°C.

This image is courtesy of an Abreview submitted by Carter Yang

IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemical analysis of paraffin-embedded (A) Colon tissue from wild-type C57BL/6JGpt mice and (B) Colon tissue from Alox15 knockout mice tissue labeling 15 Lipoxygenase 1 with ab244205 at 1/1000 dilution, followed by a ready to use LeicaDS9800 (Bond^™ Polymer Refine Detection).

Positive staining on (A) Colon tissue from wild-type C57BL/6JGpt mice and no staining on (B) Colon tissue from Alox15 knockout mice.
The section was incubated with ab244205 for 30 mins at room temperature.
The immunostaining was performed on a Leica Biosystems BOND^® RX instrument.
The tissue samples were kindly provided by GemPharmatech. C57BL/6JGpt wildtype mice and Alox15-KO homozygous mice (Strain ID : T027316).

Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond^™ Polymer Refine Detection).

Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemical analysis of paraffin-embedded mouse colon tissue labeling 15 Lipoxygenase 1 with ab244205 at 1/4000 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) Ready to use. Positive staining in eosinophils of mouse colon (PMID : 30118527; PMID : 23503644). Counter stained with hematoxylin. Heat mediated antigen retrieval using ab93684 (Tris/EDTA buffer pH 9.0).

Secondary antibody only control : Used PBS instead of primary antibody secondary antibody is Goat Anti-Rabbit IgG H&L (HRP) Ready to use.

Immunohistochemistry (Frozen sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemical analysis of 4% paraformaldehyde-fixed 0.2% Triton X-100 permeabilized frozen mouse colon tissue labeling 15 Lipoxygenase 1 with ab244205 at 1/500 dilution followed by Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488) (ab150077) secondary antibody at 1/1000 dilution (green). Positive staining in eosinophils of mouse colon (PMID : 23503644).

The nuclear counter stain is DAPI (blue). Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).

Secondary antibody only control : Used PBS instead of primary antibody secondary antibody is Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488) (ab150077) secondary antibody at 1/1000 dilution.

Unknown

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Exposure time : Lanes 1 and 2 : 3 minutes; Lane 3 : 15 seconds.

Blocking/Dilution buffer : 5% NFDM/TBST.

The molecular weight observed is consistent with what has been described in the literature (PMID : 30118527; PMID : 1662607).

All lanes:

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (ab244205) at 1/1000 dilution

Lane 1:

Mouse lung lysate at 20 µg

Lane 2:

Rat lung lysate at 20 µg

Lane 3:

Human colon lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 75 kDa

Observed band size: 75 kDa

false

Lab

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

The tissue samples were kindly provided by GemPharmatech. C57BL/6JGpt wildtype mice and Alox15-KO homozygous mice (Strain ID : T027316).

In Western blot, Anti-GAPDH antibody [EPR16891] - Loading Control (ab181602) staining at 1/200000 dilution.

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

All lanes:

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (ab244205) at 1/1000 dilution

Lane 1:

Wild-type mouse colon tissue lysate (male)

Lane 2:

Alox15 knockout colon tissue lysate (male)

Lane 3:

Wild-type mouse colon tissue lysate (female)

Lane 4:

Alox15 knockout colon tissue lysate (female)

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 75 kDa

false

Exposure time: 38s

Unknown

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Blocking/Dilution buffer : 5% NFDM/TBST.

The molecular weight observed is consistent with what has been described in the literature (PMID : 30118527; PMID : 1662607).

All lanes:

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (ab244205) at 1/1000 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) transfected with an empty vector (vector control), containing a myc-His-tag®, whole cell lysate at 10 µg

Lane 2:

HEK-293 transfected with 15 Lipoxygenase 1 (WT) expression vector containing a myc-His-tag®, whole cell lysate at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 75 kDa

Observed band size: 75 kDa

false

Exposure time: 3s

不同偶联物与剂型 (1)

Carrier free

Anti-15 Lipoxygenase 1 antibody [EPR22138] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR22138

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

IHC-P, ICC/IF, WB, IHC-Fr

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/4000", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "1/50", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/500", "IHCFr-species-notes": "Perform heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/4000", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/4000", "IHCP-species-notes": "" }, "Transfected cell lysate - Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

What is this antibody validated in?
Anti-15 Lipoxygenase 1 antibody [EPR22138] (ab244205) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.

What is the molecular weight of 15 Lipoxygenase 1?
Anti-15 Lipoxygenase 1 [EPR22138] (ab244205) specifically detects a band for 15 Lipoxygenase 1 (UniProt: P16050) at a molecular weight of 75kDa.

Trusted by the scientific community
Anti-15 Lipoxygenase 1 [EPR22138] (ab244205) was first used in a scientific publication in 2018 and has been cited over 10 times in peer-reviewed journals.

Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Specificity confirmed
The specificity of Anti-15 Lipoxygenase 1 antibody [EPR22138] (ab244205) has been confirmed by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) testing in ALOX15 Knockout Mouse Colon samples.

Other related products
We have a range of other formats of antibody clone [EPR22138] also available for your convenience: ab244205, Carrier free - ab245201

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

15-Lipoxygenase 1 also known as 15-LOX-1 is an enzyme with significant mechanical roles in the human body. Its main function is to catalyze the oxidation of fatty acids especially converting arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HPETE). The protein has other names like arachidonate 15-lipoxygenase or 15-LO. The molecular weight of 15-LOX-1 is approximately 75 kDa. It is mainly expressed in cells of the reticulocyte and tracheobronchial epithelium as well as in macrophages and eosinophils.

Biological function summary

15-Lipoxygenase 1 plays a role in the immune and inflammatory responses. It is involved in lipid mediator biosynthesis producing reactive lipids that influence cell signaling and modulate reactions to inflammation. 15-LOX-1 acts as part of a complex with other enzymes within the lipoxygenase family which includes 5-lipoxygenase and 12-lipoxygenase. This enzyme can also be important for cell maturity and has roles in cell differentiation and maturation particularly in inflamed tissues.

Pathways

Several significant processes involve 15-Lipoxygenase 1 especially its part in the arachidonic acid metabolism and the linoleic acid pathway. In these pathways 15-LOX-1 transforms substances into various lipid signaling molecules like lipoxins and resolvins. These molecules have connections with other proteins like cyclooxygenase-2 (COX-2) and 5-LO which participate in the synthesis of other eicosanoids. The interplay of these pathways and proteins helps in regulating inflammation and resolving it ensuring a balanced biological response to stimuli.

15-Lipoxygenase 1 has associations with conditions including asthma and atherosclerosis. In asthma the enzyme contributes to the inflammatory changes observed in affected airways. Its involvement in this respiratory disorder links it with proteins such as LTC4 synthase that generate pro-inflammatory leukotrienes. In atherosclerosis 15-LOX-1 interacts with oxidized low-density lipoprotein (LDL) in arterial walls which contributes to plaque formation and the associated chronic inflammation. These roles reveal the enzyme's significance in both chronic inflammation and cardiovascular disease settings.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed : 17052953, PubMed : 1944593, PubMed : 24282679, PubMed : 25293588, PubMed : 32404334, PubMed : 8334154). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed : 17052953, PubMed : 1944593, PubMed : 24282679, PubMed : 8334154). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (PubMed : 8334154). May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed : 32404334). Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (PubMed : 25293588). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed : 21831839).

See full target information ALOX15

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文献 (32)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8030 PubMed40877267

2025

Organic-inorganic covalent selenium reversing ischemic reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zushuang Xiong,Guanning Huang,Jia-Run Huang,Ying Liu,Lizhen He,Tianfeng Chen

Journal of orthopaedic translation 52:344-359 PubMed40485847

2025

GPX4 activator enhances neuroprotection and functional recovery in spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xinjie Liu,Yilin Pang,Baoyou Fan,Jiawei Zhang,Shen Liu,Xiaobing Deng,Yun Li,Ying Liu,Xu Zhang,Chenxi Zhao,Xiaoyu Wang,Xudong Wu,Luhua Lai,Shiqing Feng,Wenpeng Liu,Guangzhi Ning,Xue Yao

CNS neuroscience & therapeutics 31:e70440 PubMed40387519

2025

ALOX15-Mediated Neuron Ferroptosis Was Involved in Diabetic Peripheral Neuropathic Pain.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiye Feng,Fuye Li,Zhiqiang Lin,Jian Liu,Xi Chen,Wenxu Yan,Zhongjie Liu

Chinese herbal medicines 17:148-155 PubMed39949807

2025

Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Cuiping Long,Qian Zhou,Min Xu,Xin Ding,Xingxing Zhang,Ya Zhang,Yuping Tang,Guangguo Tan

Cellular and molecular gastroenterology and hepatology 19:101448 PubMed39943905

2025

The Protective Role of DDIT4 in Helicobacter pylori-induced Gastric Metaplasia Through Metabolic Regulation of Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Wang,Xinbo Xu,Yaobin Ouyang,Xiao Fei,Cong He,Xianhe Yang,Yuping Ren,Yanan Zhou,Sihai Chen,Yi Hu,Jianping Liu,Zhongming Ge,William Ka Kei Wu,Nonghua Lu,Chuan Xie,Xidong Wu,Yin Zhu,Nianshuang Li

International journal of biological sciences 21:1275-1293 PubMed39897035

2025

Exosomal mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Zhang,Pei Qiao,ChunYing Xiao,ZiPeng Cao,JiaoLing Chen,Hui Fang,JianKang Yang,ZeHua Kang,ErLe Dang,Shuai Shao,BingYu Pang,QingYang Li,ZhenLai Zhu,ShengXian Shen,Akito Hasegawa,Riichiro Abe,HongJiang Qiao,Gang Wang,Meng Fu

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2412282 PubMed39887620

2025

Unraveling the Microenvironment and the Pathogenic Axis of HIF-1α-Visfatin-Fibrosis in Autoimmune Pancreatitis Using a Single-Cell Atlas.

Applications

Unspecified application

Species

Unspecified reactive species

Deyu Zhang,Congjia Ma,Zhen Wang,Yanfang Liu,Zaoqu Liu,Wanshun Li,Yue Liu,Chang Wu,Liqi Sun,Fei Jiang,Hui Jiang,Xiaoju Su,Lisi Peng,Jiayu Li,Xinyue Wang,Hua Yin,Dongling Wan,Yuyan Zhou,Xiaorong Tian,Shiyu Li,Zhendong Jin,Baoan Ji,Zhaoshen Li,Haojie Huang

iScience 27:111005 PubMed39474068

2024

AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Liting Cheng,Mingxiang Zhu,Xiang Xu,Xin Li,Yongming Yao,Chunlei Liu,Kunlun He

International journal of molecular sciences 25: PubMed39457099

2024

SAT1/ALOX15 Signaling Pathway Is Involved in Ferroptosis After Skeletal Muscle Contusion.

Applications

Unspecified application

Species

Unspecified reactive species

Huihuang Yang,Yingmin Li,Weihao Zhu,Xiaowei Feng,Hongjian Xin,Hao Chen,Guozhong Zhang,Min Zuo,Bin Cong,Weibo Shi

Journal of immunology (Baltimore, Md. : 1950) 213:1212-1224 PubMed39230290

2024

MAFB in Macrophages Regulates Prostaglandin E2-Mediated Lipid Mediator Class Switch through ALOX15 in Ischemic Acute Kidney Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Maho Kanai,Teppei Nishino,Dhouha Daassi,Akari Kimura,Ching-Wei Liao,Zeynab Javanfekr Shahri,Arata Wakimoto,Natalia Gogoleva,Toshiaki Usui,Naoki Morito,Makoto Arita,Satoru Takahashi,Michito Hamada

View all publications

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For licensing inquiries, please contact partnerships@abcam.com

重组Anti-15 Lipoxygenase 1抗体[EPR22138]

Anti-15 Lipoxygenase 1 antibody [EPR22138]

Immunocytochemistry/ Immunofluorescence - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunocytochemistry/ Immunofluorescence - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunocytochemistry - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Immunohistochemistry (Frozen sections) - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

Western blot - Anti-15 Lipoxygenase 1 antibody [EPR22138] (AB244205)

不同偶联物与剂型 (1)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原

反应性数据

产品详情

性能和储存信息

形式

纯化工艺

存储溶液

运输条件

推荐的短期储存时间

推荐的短期储存条件

推荐的长期储存条件

分装信息

储存信息

补充信息

Biological function summary

Pathways

产品实验方案

靶点信息

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