Anti-14-3-3 Theta + Tau (phospho S232)抗体(ab63369)
Key features and details
- Rabbit polyclonal to 14-3-3 Theta + Tau (phospho S232)
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-14-3-3 Theta + Tau (phospho S232)抗体
参阅全部 14-3-3 Theta + Tau 一抗 -
描述
兔多克隆抗体to 14-3-3 Theta + Tau (phospho S232) -
宿主
Rabbit -
特异性
ab63369 detects 14-3-3 Theta + Tau only when phosphorylated at serine 232.
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经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Mouse
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免疫原
Synthetic peptide corresponding to Human 14-3-3 Theta + Tau (phospho S232). (S-D-SP-A-G).
Database link: P27348 -
阳性对照
- ICC/IF: HeLa cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab63369于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
1/500 - 1/1000.
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| 说明 |
|---|
|
ICC/IF
1/500 - 1/1000. |
靶标
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功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. -
组织特异性
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. -
序列相似性
Belongs to the 14-3-3 family. -
翻译后修饰
Ser-232 is probably phosphorylated by CK1. -
细胞定位
Cytoplasm. In neurons, axonally transported to the nerve terminals. - Information by UniProt
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数据库链接
- Entrez Gene: 10971 Human
- Entrez Gene: 100503129 Mouse
- Entrez Gene: 22630 Mouse
- Omim: 609009 Human
- SwissProt: P27348 Human
- SwissProt: P68254 Mouse
- Unigene: 611799 Human
- Unigene: 74405 Human
see all -
别名
- 14-3-3 protein T cell antibody
- 14-3-3 protein T-cell antibody
- 14-3-3 protein tau antibody
see all
图片
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Immunocytochemistry/ Immunofluorescence - Anti-14-3-3 Theta + Tau (phospho S232) antibody (ab63369)ab63369 at 1/500 dilution staining 14-3-3 Tau in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab63369 被引用在 1 文献中.
- McFerrin MB et al. Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology. Ann Clin Transl Neurol 4:466-477 (2017). PubMed: 28695147