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AB178654

Anti-Rubella Virus IgM ELISA试剂盒

Anti-Rubella Virus IgM ELISA Kit

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Anti-Rubella Virus IgM ELISA Kit is an sandwich ELISA for the qualitative detection of IgM class antibodies against Rubella Virus in human plasma and serum samples.

- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation

关键信息

检测方法

Colorimetric

样品类型

Citrate plasma, Heparin Plasma, Serum

检测类型

Sandwich

检测平台

Microplate

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Abcam's anti-Rubella Virus IgM in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgM class antibodies against Rubella Virus in Human serum and plasma.

A 96-well plate has been precoated with anti-Human IgM antibodies to bind to corresponding antibodies of the sample. Controls or test samples are added to the wells and incubated. Following washing, a horseradish peroxidase (HRP) labelled Rubella Virus antigen conjugate is added to the wells, which binds to the captured Rubella Virus-specific IgM antibodies. TMB is then catalyzed by the HRP to produce a blue color product that changes to yellow after adding an acidic stop solution. The density of yellow coloration is directly proportional to the amount of Rubella Virus IgM sample captured in plate.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

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精确度

[ { "reproducibilityType": "Inter", "sample": "Serum", "replicates": 3, "mean": null, "standardDeviation": null, "coefficientOfVariability": "10.3" }, { "reproducibilityType": "Inter", "sample": "Serum", "replicates": 3, "mean": null, "standardDeviation": null, "coefficientOfVariability": "11.5" }, { "reproducibilityType": "Intra", "sample": "Serum", "replicates": 23, "mean": null, "standardDeviation": null, "coefficientOfVariability": "2.7" }, { "reproducibilityType": "Intra", "sample": "Serum", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "4" } ]
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规格

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab178654-1x96Tests", "assetComponentDetails": [ { "size":"1 x 12 mL", "name":"Rubella Virus HRP Conjugate", "number":"AB178654-CMP07", "productcode":"" }, { "size":"1 x 100 mL", "name":"IgM Sample Diluent", "number":"AB178654-CMP03", "productcode":"" }, { "size":"1 x 3 mL", "name":"Rubella Virus IgM Cut-off Control", "number":"AB178654-CMP06", "productcode":"" }, { "size":"1 x 2 mL", "name":"Rubella Virus IgM Negative Control", "number":"AB178654-CMP08", "productcode":"" }, { "size":"1 x 2 mL", "name":"Rubella Virus IgM Positive Control", "number":"AB178654-CMP09", "productcode":"" }, { "size":"1 x 50 mL", "name":"20X Washing Solution", "number":"AB178654-CMP05", "productcode":"" }, { "size":"1 x 15 mL", "name":"Stop Solution", "number":"AB178654-CMP10", "productcode":"" }, { "size":"1 x 15 mL", "name":"TMB Substrate Solution", "number":"AB178654-CMP04", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Cover Foil", "number":"AB178654-CMP01", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Anti-Human IgM Coated Microplate (12 x 8 wells)", "number":"AB178654-CMP02", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Strip holder", "number":"AB178654-CMP11", "productcode":"" } ] } } }
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Rubella Virus IgM also known as Anti-Rubella IgM is an immunoglobulin M antibody that forms specifically in response to Rubella virus infection. This antibody with a molecular weight of approximately 180 kDa serves as an early marker of Rubella virus exposure during primary infection. Rubella Virus IgM can be detected in the blood of individuals as soon as one to two weeks after the initial infection. Its presence indicates a recent or current infection distinguishing it from Rubella IgG antibodies which persist long-term.
Biological function summary

Antibodies like Rubella Virus IgM play an important role in the immune response by neutralizing the Rubella virus and preventing viral replication. The production of IgM antibodies occurs early during the immune response and it does not typically form part of a larger complex. The initiation of Rubella-specific IgM synthesis leads to an effective defense against viral pathogens before the body transitions to a predominant IgG response which aids in forming long-term immunity.

Pathways

The immune response associated with Rubella Virus IgM involves the broader adaptive immune system pathway engaging multiple effector mechanisms to combat viral infections. This involves activation and coordination with cytokine signaling pathways and collaboration with other immune components such as T-helper cells. The coordination ensures immediate containment of the virus while also facilitating a memory response through IgG antibody production.

Rubella Virus IgM plays a pivotal role in the diagnosis of acute Rubella infection. It is of particular concern in congenital rubella syndrome when the virus transmits from mother to fetus leading to serious birth defects. Antibodies like Anti-Rubella IgM could offer critical insight into maternal-fetal infections. The presence and detection of Rubella Virus IgM are essential for public health monitoring and prevention strategies providing timely interventions during outbreaks.
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产品实验方案

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靶点信息

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websiteProtocolBooklet
en
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