AB289835

大鼠Calcitonin ELISA试剂盒

Name: 大鼠Calcitonin ELISA试剂盒 (ab289835)| Abcam中文官网
Brand: Abcam Limited
SKU: AB289835
Price: 6589 CNY
Availability: InStock

Rat Calcitonin ELISA Kit

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Rat Calcitonin ELISA Kit is a Sandwich ELISA for the measurement of Rat Calcitonin in Rat in Biofluids samples.

查看别名

Calc, Calca, Calcitonin

1 Images

Sandwich ELISA - Rat Calcitonin ELISA Kit (AB289835)

sELISA

Supplier Data

Sandwich ELISA - Rat Calcitonin ELISA Kit (AB289835)

Typical Standard Curve using ab289835. A new standard curve should be run with each assay.

关键信息

检测方法

Colorimetric

样品类型

Plasma, Serum, Other biological fluids

反应种属

Rat

检测类型

Sandwich

灵敏度

= 9.38 pg/mL

范围

15.63 - 1000 pg/mL

检测平台

Microplate (12 x 8 well strips)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

This Rat Calcitonin ELISA ab289835 (previously known as #E4745) kit is an in vitro ELISA for the quantitative measurement of rat Calcitonin through sandwhich ELISA. This assay employs an antibody specific for rat Calcitonin coated on a 96-well plate.

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精确度

[ { "reproducibilityType": "Inter", "sample": "Overall", "replicates": 0, "mean": null, "standardDeviation": null, "coefficientOfVariability": "4.76" }, { "reproducibilityType": "Intra", "sample": "Overall", "replicates": 0, "mean": null, "standardDeviation": null, "coefficientOfVariability": "5.03" } ]

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规格

{ "values": { "96Test": { "sellingSize": "96 Test", "publicAssetCode":"ab289835-96Test", "assetComponentDetails": [ { "size":"1 x 10 mL", "name":"Stop Solution", "number":"AB289835-CMP07", "productcode":"" }, { "size":"1 x 30 mL", "name":"25X Wash buffer", "number":"AB289835-CMP11", "productcode":"" }, { "size":"4 x 1 Unit", "name":"Plate Sealer", "number":"AB289835-CMP05", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Standard", "number":"AB289835-CMP03", "productcode":"" }, { "size":"1 x 14 mL", "name":"Biotinylated Detection Antibody Diluent", "number":"AB289835-CMP02", "productcode":"" }, { "size":"1 x 120 µL", "name":"HRP Conjugate (100x)", "number":"AB289835-CMP08", "productcode":"" }, { "size":"1 x 10 mL", "name":"Substrate Reagent", "number":"AB289835-CMP10", "productcode":"" }, { "size":"1 x 14 mL", "name":"HRP Conjugate Diluent", "number":"AB289835-CMP09", "productcode":"" }, { "size":"1 x 20 mL", "name":"Standard & Sample Diluent", "number":"AB289835-CMP06", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Micro ELISA Plate", "number":"AB289835-CMP04", "productcode":"" }, { "size":"1 x 120 µL", "name":"Biotinylated Detection Antibody (100x)", "number":"AB289835-CMP01", "productcode":"" } ] } } }

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性能和储存信息

运输条件

Blue Ice

储存信息

Please refer to protocols

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Calcitonin also known as thyrocalcitonin is a peptide hormone with a molecular mass of about 3.4 kDa. It consists of 32 amino acids and is primarily synthesized in parafollicular cells or C cells of the thyroid gland. This hormone regulates calcium and phosphate homeostasis in the body. It reduces blood calcium levels by inhibiting osteoclast activity in the bones and decreasing reabsorption in the kidneys leading to more calcium excretion. Calcitonin also interacts with its receptor a G protein-coupled receptor found in tissues like bone kidney and brain.

Biological function summary

This hormone plays a significant role in maintaining calcium levels by balancing the actions of parathyroid hormone (PTH). Calcitonin works independently but interacts with the broader system managing bone remodeling through an intricate network. The presence of calcitonin in specialized receptor complexes allows it to exert its effects efficiently in target tissues making it an important player in calcium and phosphorus metabolism.

Pathways

Calcitonin acts within the calcium signaling pathway and the bone resorption pathway. Through these pathways calcitonin works alongside other proteins such as parathyroid hormone (PTH) and calcitonin gene-related peptide (CGRP) maintaining skeletal integrity. It modulates the activity of osteoclasts ensuring that bone resorption activities are counterbalanced by bone formation and influences intracellular calcium concentration by binding to its receptor on target cells.

Calcitonin is linked to conditions such as osteoporosis and medullary thyroid carcinoma. Osteoporosis characterized by decreased bone density and increased fracture risk involves dysregulated calcium and phosphate balance. Proteins like estrogen and growth factors along with calcitonin influence bone health. Medullary thyroid carcinoma a type of thyroid cancer arising from C cells affects calcitonin levels with this hormone serving as a biomarker for diagnosing and monitoring treatment effectiveness. Calcitonin's connection with these diseases highlights its diagnostic and therapeutic potential.

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产品实验方案

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靶点信息

Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (By similarity).

See full target information Calca

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websiteProtocolBooklet

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大鼠Calcitonin ELISA试剂盒

Rat Calcitonin ELISA Kit

Sandwich ELISA - Rat Calcitonin ELISA Kit (AB289835)