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AB314388

人SCGF ELISA试剂盒

Human SCGF ELISA Kit

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Human SCGF ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human SCGF in Human in Biofluids, Cell Culture Media samples.

查看别名

CLECSF3, LSLCL, SCGF, CLEC11A, C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47

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Sandwich ELISA - Human SCGF ELISA Kit (AB314388)
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Supplier Data

Sandwich ELISA - Human SCGF ELISA Kit (AB314388)

Example of standard curve using ab314388. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

关键信息

检测方法

Colorimetric

样品类型

Serum, Plasma, Cell culture supernatant

反应种属

Human

检测类型

Sandwich (quantitative)

灵敏度

= 0.038 ng/mL

范围

0.038 - 10 ng/mL

检测平台

Pre-coated microplate (12 x 8 well strips)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Human SCGF ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human SCGF in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human SCGF coated on a 96-well plate.
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回收率

[ { "sample": "Serum", "range": "104 - 117 %", "average": "= 110.6" }, { "sample": "Plasma", "range": "93 - 111 %", "average": "= 104.3" }, { "sample": "Cell culture media", "range": "70 - 85 %", "average": "= 77.24" } ]
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规格

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab314388-1x96Tests", "assetComponentDetails": [ { "size":"1 x 200 µL", "name":"200X HRP-Streptavidin", "number":"AB314388-CMP03", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB314388-CMP05", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human SCGF Antibody-coated ELISA Plate", "number":"AB314388-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human SCGF Detection Antibody", "number":"AB314388-CMP09", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB314388-CMP07", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB314388-CMP06", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB314388-CMP04", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human SCGF Protein Standard", "number":"AB314388-CMP10", "productcode":"" } ] } } }
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
-20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Stem Cell Growth Factor (SCGF) also known as C-type lectin domain family 11 member A (CLEC11A) is a glycoprotein with a mass around 38 kDa. It mechanically functions by promoting mitogenic and survival activities on hematopoietic progenitors which are essential for blood cell formation. SCGF is mainly expressed in the bone marrow as well as in several other tissues such as the pancreas and liver where it plays significant roles.
Biological function summary

SCGF plays a significant role in the development and regulation of the hematopoietic system. It supports the proliferation and differentiation of a variety of blood cell lineages. SCGF does not belong to a complex but interacts with other soluble factors like cytokines and growth factors to exert its functions. It enhances the actions of colony-stimulating factors emphasizing its role in hematopoiesis.

Pathways

SCGF is important in the regulation of the hematopoietic growth pathways. It is involved in the cytokine-cytokine receptor interaction pathway which assists in signaling and communication between cells. SCGF shows interactions with proteins like FLT3 which play a role in the development and survival of blood cell precursors. This intricate network bolsters the adaptive and innate immune systems by promoting the production and function of necessary blood cells.

Disruptions in SCGF activity can influence both hematological and autoimmune disorders. Alterations in SCGF expression have connections to leukemia where abnormal proliferation of blood cells occurs. Additionally its dysregulation may contribute to autoimmune diseases where the immune system mistakenly attacks the body. In these contexts SCGF relates with the cytokine IL-6 which is also involved in immune responses and inflammation further underlining SCGF's influence on disease mechanisms.
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产品实验方案

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靶点信息

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed : 27976999). Important for repair and maintenance of adult bone (By similarity).
See full target information CLEC11A
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websiteProtocolBooklet
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搭配使用产品

Primary Antibodies

AB90238

Anti-SCGF antibody [MM0533-6D5]

Western blot - Anti-SCGF antibody [MM0533-6D5] (AB90238)

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