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AB313920

人PCDH17 ELISA试剂盒

Human PCDH17 ELISA Kit

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Human PCDH17 ELISA Kit is a Sandwich ELISA for the measurement of Human PCDH17 in Human in Cell Culture Media, Biofluids samples.

查看别名

PCDH68, PCH68, PCDH17, Protocadherin-17, Protocadherin-68

1 Images
Sandwich ELISA - Human PCDH17 ELISA Kit (AB313920)
  • sELISA

Supplier Data

Sandwich ELISA - Human PCDH17 ELISA Kit (AB313920)

Example of standard curve using ab313920. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

关键信息

检测方法

Colorimetric

样品类型

Cell culture supernatant, Plasma, Serum

反应种属

Human

检测类型

Sandwich

Quantitative
灵敏度

= 0.045 ng/mL

范围

0.045 - 10 ng/mL

检测平台

Pre-coated microplate (12 x 8 well strips)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Human PCDH17 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human PCDH17 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human Protocadherin-17 coated on a 96-well plate.

This ELISA kit shows no cross-reactivity with the following cytokines tested: human Activin C, AHCY, APE, Bax, BNIP3, Caspase-3, Cathepsin F, CD177, CD96, CLEC4D, C-Peptide, DCBLD2, Dystroglycan, FAM3A, GCNT1, GLA, HAPLN4, hCG alpha, HMGB3, IkB-E, IRF4, KIR3DL1, Klotho beta, Lck, LILRA5, METTL11A, p55PIK, PLA2G4A, RalB, S100A2, S100B, SH2B1, Siglec-3, SOD3, ST8SIA2, Testican 1, TRP14, VAP-B, ZAP70.

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回收率

[ { "sample": "Serum", "range": "89 - 93 %", "average": "= 90.55" }, { "sample": "Plasma", "range": "85 - 99 %", "average": "= 92.48" }, { "sample": "Cell culture media", "range": "71 - 95 %", "average": "= 82.85" } ]
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规格

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313920-1x96Tests", "assetComponentDetails": [ { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313920-CMP04", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human PCDH17 Antibody-coated ELISA Plate", "number":"AB313920-CMP08", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313920-CMP05", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human PCDH17 Protein Standard", "number":"AB313920-CMP10", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313920-CMP06", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313920-CMP07", "productcode":"" }, { "size":"1 x 200 µL", "name":"300X HRP-Streptavidin", "number":"AB313920-CMP03", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human PCDH17 Detection Antibody", "number":"AB313920-CMP09", "productcode":"" } ] } } }
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
-20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PCDH17 also known as protocadherin-17 is a protein involved in cell-cell adhesion. This protein is a member of the protocadherin family which is part of the cadherin superfamily. It has a molecular weight of approximately 120 kDa. PCDH17 contains cadherin-like domains which facilitate calcium-dependent cell adhesion. The protein is mainly expressed in the brain especially in regions associated with memory and learning such as the hippocampus and the cerebral cortex.
Biological function summary

Protocadherin-17 influences neural circuit formation and maintenance. It acts as a member of trans-synaptic complexes that modulate the connectivity and signaling efficiency between neurons. This protein plays a important role in the reorganization of synaptic connections during neuronal development and in response to environmental stimuli. Studies indicate its contribution to the stabilization of cell-cell interactions necessary for maintaining synaptic specificity.

Pathways

Protocadherin-17 integrates into complex neural pathways involved in synaptic plasticity and neurodevelopment. It interacts with other members of the cadherin family like N-cadherin to modulate synaptic structures and signaling cascades. PCDH17 potentially influences pathways related to calcium signaling which are essential for various neural processes.

Alterations in protocadherin-17 expression have been associated with neurological conditions such as epilepsy and schizophrenia. Abnormal expression or mutations in this protein may disrupt synaptic connectivity and function contributing to the pathophysiology of these disorders. Connections between PCDH17 and other cadherins as well as neurotransmitter receptors may influence disease states where aberrant signaling and cell adhesion play roles.
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产品实验方案

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靶点信息

Potential calcium-dependent cell-adhesion protein.
See full target information PCDH17
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websiteProtocolBooklet
en
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