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AB309396

人LTBR ELISA试剂盒

Human LTBR ELISA Kit

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Human LTBR ELISA Kit is a Sandwich ELISA for the measurement of Human LTBR in Human in Cell Culture Media, Biofluids samples.

查看别名

D12S370, TNFCR, TNFR3, TNFRSF3, LTBR, Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III

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Sandwich ELISA - Human LTBR ELISA Kit (AB309396)
  • sELISA

Supplier Data

Sandwich ELISA - Human LTBR ELISA Kit (AB309396)

Example of standard curve using ab309396. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

关键信息

检测方法

Colorimetric

样品类型

Cell culture supernatant, Plasma, Serum

反应种属

Human

检测类型

Sandwich

灵敏度

= 4.5 pg/mL

范围

4.5 - 1000 pg/mL

检测平台

Pre-coated microplate (12 x 8 well strips)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Human LTBR ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human LTBR in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for human LTBR coated on a 96-well plate.
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回收率

[ { "sample": "Cell culture media", "range": "96 - 104 %", "average": "= 98.86" }, { "sample": "Plasma", "range": "102 - 124 %", "average": "= 113.2" }, { "sample": "Serum", "range": "110 - 115 %", "average": "= 111.6" } ]
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规格

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab309396-1x96Tests", "assetComponentDetails": [ { "size":"2 x 1 Vial", "name":"Lyophilized Human Lymphotoxin beta R/TNF RIII/TNFRSF3 Protein Standard", "number":"AB309396-CMP10", "productcode":"" }, { "size":"1 x 200 µL", "name":"150X HRP-Streptavidin", "number":"AB309396-CMP11", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB309396-CMP05", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB309396-CMP06", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB309396-CMP07", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human Lymphotoxin beta R/TNF RIII/TNFRSF3 Antibody-coated ELISA Plate", "number":"AB309396-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human Lymphotoxin beta R/TNF RIII/TNFRSF3 Detection Antibody", "number":"AB309396-CMP09", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB309396-CMP04", "productcode":"" } ] } } }
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
-20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LTBR (lymphotoxin beta receptor) also known as the TNFRSF3 is a significant protein that functions as a receptor for lymphotoxin and other related cytokines. The protein has a mass of around 62 kDa and is expressed in various tissues including lymphoid tissues and the epithelial cells of several organs. LTBR is present as a membrane-bound protein and helps mediate signaling that is important for cellular communication and function. Key interactions with ligands such as LTA and LIGHT activate signaling pathways which play roles in immune response.
Biological function summary

LTBR coordinates multiple cellular processes especially in immune regulation and homeostasis. It forms a complex with cytokines that binds to its extracellular domain triggering downstream signaling cascades. These cascades lead to activation of nuclear factor kappa B (NF-kB) which controls gene transcription and promotes survival and differentiation of immune cells. The capability of LTBR to interact with other TNF receptors expands its influence in lymphoid organogenesis and maintenance especially in maintaining the integrity of the lymphoid system.

Pathways

LTBR significantly participates in both the NF-kB and the non-canonical NF-kB pathways. These pathways are essential for regulating immune response and inflammation. Within these pathways LTBR interacts with other proteins such as TRAF3 and TRAF2 to mediate signaling processes. This arrangement allows for modulation of immune responses and is critical for recognizing and eliminating pathogens. Additionally the involvement of LTBR in immune system pathways aligns it with the functions of closely related proteins like TNF receptor superfamily members.

LTBR has been implicated in autoimmune diseases and cancer. In autoimmunity aberrant signaling through LTBR may lead to inappropriate immune responses and inflammation as seen in disorders like systemic lupus erythematosus. Moreover in oncology abnormalities in LTBR signaling can influence tumor microenvironments and support tumor cell survival. Throughout these disease contexts LTBR often interacts with other risk-associated proteins such as NFKB1 highlighting its integration in complex pathological processes.
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产品实验方案

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靶点信息

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT (PubMed : 24248355). Activates NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA(1)-LTB(2)) (PubMed : 24248355). Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
See full target information LTBR
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搭配使用产品

Primary Antibodies

AB320846

Anti-LTBR antibody [RM2069] - BSA and Azide free

Recombinant|RabMAb

Flow Cytometry - Anti-LTBR antibody [RM2069] - BSA and Azide free (AB320846)

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Proteins & Peptides

AB198752

Recombinant Mouse LTBR protein (Fc tag C-Terminus)

SDS-PAGE - Recombinant Mouse LTBR protein (Fc tag C-Terminus) (AB198752)

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