AB313988

人LTBP2 ELISA试剂盒

Name: 人LTBP2 ELISA试剂盒 (ab313988)| Abcam中文官网
Brand: Abcam Limited
SKU: AB313988
Price: 6658 CNY
Availability: InStock

Human LTBP2 ELISA Kit

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Human LTBP2 ELISA Kit is a sandwich ELISA designed to quantify Human LTBP2 with a sensitivity of 17.5 pg/mL.

- Colorimetric sandwich ELISA - 450 nm readout - works on any plate reader
- Wide dynamic range - quantifies 17.5 - 5000 pg/mL

查看别名

C14orf141, LTBP3, LTBP2, Latent-transforming growth factor beta-binding protein 2, LTBP-2

1 Images

Sandwich ELISA - Human LTBP2 ELISA Kit (AB313988)

sELISA

Supplier Data

Sandwich ELISA - Human LTBP2 ELISA Kit (AB313988)

Example of standard curve using ab313988. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

关键信息

检测方法

Colorimetric

样品类型

Serum, Plasma, Cell culture supernatant

反应种属

Human

检测类型

Sandwich

灵敏度

= 17.5 pg/mL

范围

17.5 - 5000 pg/mL

检测平台

Pre-coated microplate (12 x 8 well strips)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

Human LTBP2 ELISA Kit ab313988 is a sandwich ELISA to measure Human LTBP2 in serum, plasma, cell culture supernatant with a sensitivity of 17.5 pg/ml.

How the assay works

This assay employs an antibody specific for human LTBP2 coated on a 96-well plate.

Assay Specificity

Our ELISA kits are rigorously validated to ensure the highest level of consistency and reproducibility. Please check the protocol booklet for more details

Human LTBP2 ELISA Kit ab313988 protocol summary

1. Add standard or sample to each well used. Incubate at room temperature
2. Wash and add prepared biotinylated antibody to each well. Incubate at room temperature.
3. Wash and add prepared streptavidin solution. Incubate at room temperature.
4. Add TMB Development Solution to each well. Incubate at room temperature.
5. Add Stop Solution to each well. Read at 450nm immediately.

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回收率

[ { "sample": "Serum", "range": "101 - 123 %", "average": "= 112.5" }, { "sample": "Plasma", "range": "98 - 120 %", "average": "= 107.3" }, { "sample": "Cell culture media", "range": "93 - 105 %", "average": "= 100.4" } ]

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规格

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313988-1x96Tests", "assetComponentDetails": [ { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313988-CMP07", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human LTBP2 Protein Standard", "number":"AB313988-CMP10", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human LTBP2 Antibody-coated ELISA Plate", "number":"AB313988-CMP08", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human LTBP2 Detection Antibody", "number":"AB313988-CMP09", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313988-CMP06", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313988-CMP04", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB313988-CMP05", "productcode":"" }, { "size":"1 x 200 µL", "name":"150X HRP-Streptavidin", "number":"AB313988-CMP03", "productcode":"" } ] } } }

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性能和储存信息

运输条件

Blue Ice

储存信息

-20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LTBP2 also known as latent transforming growth factor-beta binding protein 2 is a glycoprotein involved in the regulation of transforming growth factor-beta (TGF-β) signaling. This protein has a mass of approximately 195 kDa. LTBP2 is expressed in a variety of tissues including the lungs heart and eyes. It plays an important role in the extracellular matrix where it is fundamental to the sequestration and subsequent activation of TGF-β.

Biological function summary

LTBP2 interacts with the extracellular matrix components and acts as a structural protein. LTBP2 is an important part of TGF-β complexes. By anchoring TGF-β in a latent form it controls the availability and activation of TGF-β which is necessary for processes like cell growth differentiation and tissue repair. Without LTBP2 the controlled release of TGF-β can be disrupted impacting various cell functions.

Pathways

LTBP2 regulates the TGF-β signaling pathway and maintains its equilibrium. This regulatory function links LTBP2 to the pathways involving cell proliferation and differentiation. LTBP2 closely interacts with other members of the LTBP family as well as proteins like fibrillin which are involved in the structural integrity of the extracellular matrix. These interactions are significant for maintaining proper signal transduction and cellular responses.

LTBP2 mutations have associations with conditions such as glaucoma and Weill-Marchesani syndrome. In glaucoma abnormalities in LTBP2 might affect the integrity of the extracellular matrix influencing intraocular pressure regulation. It also connects to fibrillin-related disorders due to its interaction with fibrillin proteins. These associations highlight the importance of LTBP2 in both structural and signaling roles within the body.

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产品实验方案

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靶点信息

May play an integral structural role in elastic-fiber architectural organization and/or assembly.

See full target information LTBP2

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websiteProtocolBooklet

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人LTBP2 ELISA试剂盒

Human LTBP2 ELISA Kit

Sandwich ELISA - Human LTBP2 ELISA Kit (AB313988)