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AB285292

人Estrogen Receptor beta ELISA试剂盒

Human Estrogen Receptor beta ELISA Kit

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Human Estrogen Receptor beta ELISA Kit is a Sandwich ELISA for the measurement of Human Estrogen Receptor beta in Human in Biofluids, Cell/Tissue Extracts samples.

查看别名

ESTRB, NR3A2, ESR2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2

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Sandwich ELISA - Human Estrogen Receptor beta ELISA Kit (AB285292)
  • sELISA

Supplier Data

Sandwich ELISA - Human Estrogen Receptor beta ELISA Kit (AB285292)

Human Estrogen Receptor beta ELISA Kit.

Typical Standard Curve : These standard curves are for demonstration only. A standard curve must be run with each assay.

关键信息

检测方法

Colorimetric

样品类型

Plasma, Tissue Homogenate, Serum

反应种属

Human

检测类型

Sandwich

Quantitative
灵敏度

< 0.188 ng/mL

范围

0.313 - 20 ng/mL

检测平台

Microplate (12 x 8 well strips)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This estrogen receptor-beta ELISA kit (ab285292, K4268) is a sandwich ELISA assay for the quantitative measurement of human estrogen receptor-beta in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of human estrogen receptor-beta captured from the samples.

This product is manufactured by BioVision, an Abcam company and was previously called K4268 Estrogen Receptor beta (ERß) (Human) ELISA Kit. K4268-100 is the same size as the 96 test size of ab285292.

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精确度

[ { "reproducibilityType": "Inter", "sample": "Overall", "replicates": 0, "mean": null, "standardDeviation": null, "coefficientOfVariability": "< 10" }, { "reproducibilityType": "Intra", "sample": "Overall", "replicates": 0, "mean": null, "standardDeviation": null, "coefficientOfVariability": "< 8" } ]
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规格

{ "values": { "96Test": { "sellingSize": "96 Test", "publicAssetCode":"ab285292-96Test", "assetComponentDetails": [ { "size":"1 x 10 mL", "name":"TMB Substrate", "number":"AB285292-CMP10", "productcode":"" }, { "size":"5 x 1 Unit", "name":"Plate Sealer", "number":"AB285292-CMP06", "productcode":"" }, { "size":"1 x 10 mL", "name":"Stop Solution", "number":"AB285292-CMP05", "productcode":"" }, { "size":"1 x 30 mL", "name":"25X Wash buffer", "number":"AB285292-CMP11", "productcode":"" }, { "size":"1 x 10 mL", "name":"SABC dilution buffer", "number":"AB285292-CMP07", "productcode":"" }, { "size":"1 x 20 mL", "name":"Sample and Standard Dilution Buffer", "number":"AB285292-CMP09", "productcode":"" }, { "size":"1 x 10 mL", "name":"Antibody dilution buffer", "number":"AB285292-CMP01", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Micro ELISA Plate", "number":"AB285292-CMP04", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Standard", "number":"AB285292-CMP03", "productcode":"" }, { "size":"1 x 120 µL", "name":"HRP-Streptavidin Conjugate (SABC)", "number":"AB285292-CMP08", "productcode":"" }, { "size":"1 x 120 µL", "name":"Biotin-Detection antibody (Concentrated)", "number":"AB285292-CMP02", "productcode":"" } ] } } }
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.
Biological function summary

Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.

Pathways

Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.

Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.
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产品实验方案

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靶点信息

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed : 20074560).. Isoform 2. Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
See full target information ESR2
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websiteProtocolBooklet
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