人APOL6 knockout A549 cell裂解物
Human APOL6 knockout A549 cell lysate
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APOL6 KO cell lysate available now. KO validated. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon2.
查看别名
2310076O14Rik, APOL6_HUMAN, ApoL-VI, Apolipoprotein L, 6, Apolipoprotein L-VI, Apolipoprotein L6, DKFZp667M075, FLJ38562, FLJ90164, MGC57495
- Sanger seq
Unknown
Sanger Sequencing - Human APOL6 knockout A549 cell lysate (AB263093)
Homozygous : 1 bp deletion in exon2
产品详情
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
规格
性能和储存信息
基因名称
基因编辑类型
基因编辑方法
敲除验证
运输条件
推荐的短期储存条件
推荐的长期储存条件
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
APOL6 influences important cellular processes such as apoptosis and lipid metabolic processes. Although not part of a large protein complex APOL6 contributes significantly to the regulation of phospholipid transport and stability within cellular membranes. Through these functions APOL6 supports cellular homeostasis and impacts the regulation of cell death pathways.
Pathways
Lipid metabolism and cell signaling heavily involve APOL6. It interacts with other apolipoproteins and factors like cholesterol transport proteins. Within the lipid metabolic pathway APOL6 facilitates proper lipid transport working closely with apolipoprotein E (ApoE) which is another key player in these processes. Disruption of this interaction can lead to imbalances in lipid homeostasis affecting overall health.
质量控制
STR 分析
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
细胞培养
生物安全等级
EU: 1 US: 1
贴壁/悬浮
Adherent
性别
Male
搭配使用产品
Abcam Product Promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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