Z-LE(OMe)VD(OMe)-FMK，derivative of Z-LEVD-FMK (ab120489)
Key features and details
- Cell-permeable derivative of caspase-4 inhibitor Z-LEVD-FMK
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Z-LE(OMe)VD(OMe)-FMK，derivative of Z-LEVD-FMK -
描述
Cell-permeable derivative of caspase-4抑制剂Z-LEVD-FMK -
别名
- Z-LEVD-FMK (cell permeable)
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生物学描述
Methylated, cell-permeable derivative of the caspase-4 inhibitor Z-Leu-Glu-Val-Asp-FMK (Z-LEVD-FMK). Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required.
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化学结构
性能
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分子量
652.72 -
分子式
C31H45FN4O10 -
序列
LEVD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem识别号
25108689 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 20 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
FCC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(C)C -
来源
Synthetic
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研究领域
相关产品
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Related Products
图片
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Chemical Structure - Z-LE(OMe)VD(OMe)-FMK, derivative of Z-LEVD-FMK (ab120489)2D chemical structure image of ab120489, Z-LE(OMe)VD(OMe)-FMK, derivative of Z-LEVD-FMK
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120489 被引用在 1 文献中.
- Dai Q et al. Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response. iScience 24:103170 (2021). PubMed: 34646996