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AB120239

Yohimbine hydrochloride，alpha2 adrenoceptor拮抗剂

Yohimbine hydrochloride, alpha2 adrenoceptor antagonist

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(3 Publications)

MW 390.9 Da, Purity >98%. Selective α2 adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors, respectively).

查看别名

ADA2A_HUMAN, ADA2C_HUMAN, ADRA2, ADRA2A, ADRA2L2, ADRA2R, ADRA2RL1, ADRA2RL2, ADRAR, ADRARL1, ADRARL2, Adra 2c, Adrenergic alpha 2A receptor, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Alpha 2 adrenergic receptor subtype C2, Alpha 2AAR subtype C10, Alpha 2B adrenoceptor, Alpha 2B adrenoreceptor, Alpha 2C adrenergic receptor subtype C4, Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C4, Alpha-2-adrenergic receptor, renal type, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-2C adrenergic receptor, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, KCNH2_HUMAN, Kv11.1, LQT 2, OTTHUMP00000058849, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, SQT1, Subtype alpha2 C4, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, alpha 2BAR, alpha-2-adrenergic receptor, platelet type, alpha2 AR C4, alpha2 C4, alpha2C, alpha2cii-adrenergic receptor, eag homolog, hERG-1

1 Images
Chemical Structure - Yohimbine hydrochloride, alpha2 adrenoceptor antagonist (AB120239)
  • Chemical Structure

Lab

Chemical Structure - Yohimbine hydrochloride, alpha2 adrenoceptor antagonist (AB120239)

2D chemical structure image of ab120239, Yohimbine hydrochloride, alpha2 adrenoceptor antagonist

关键信息

CAS 号

65-19-0

纯度

>98%

形式

Solid

form

来源

Pausinystalia yohimbe

分子量

390.9 Da

分子式

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>7</sub>ClN<sub>2</sub>O<sub>3</sub>

PubChem

6169

属性

Native

溶解度

Soluble in DMSO to 25 mM

生化试剂名称

Yohimbine hydrochloride

生物学描述

Selective α2 adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors, respectively).

经典 SMILES

COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl

同分异构的 SMILES

COC(=O)[C@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl

InChi

InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1

InChiKey

PIPZGJSEDRMUAW-VJDCAHTMSA-N

IUPAC 名

methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
The product can be stored for up to 12 months
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ADRA2B also known as alpha 2B adrenergic receptor along with alpha 2A and alpha 2C adrenergic receptors are important proteins in cellular signaling. These receptors often indicated by their gene symbol ADRA2C are expressed in various tissues including the central nervous system cardiovascular system and smooth muscle cells. The ADRA2B receptor has a mass of approximately 45-50 kDa and acts as a G protein-coupled receptor (GPCR). It interacts with norepinephrine and epinephrine modulating cellular responses through inhibition of adenylate cyclase via Gi proteins.
Biological function summary

Alpha 2B adrenergic receptor plays an important role in the regulation of neurotransmitter release in both the peripheral and central nervous systems. It operates as a part of the GPCR complex influencing functions such as vasoconstriction and platelet aggregation. By binding to endogenous agonists this receptor modulates systemic blood pressure and heart rate. Furthermore it has critical roles in modulating insulin secretion and lipolysis highlighting its diverse regulatory functions in energy metabolism.

Pathways

Alpha 2B adrenergic receptor is notably involved in the adrenergic signaling pathway and the MAPK/ERK signaling pathway. These pathways are important for stress response and cellular survival. ADRA2B's interaction with other adrenergic receptors and proteins like beta-adrenergic receptors highlights its role in coordinating physiological responses. These interactions are important for maintaining homeostasis under varying physiological conditions such as stress and exercise.

Dysfunction in alpha 2B adrenergic receptor signaling has been linked to conditions like hypertension and depressive disorders. Misregulation of this receptor affects autonomic nervous system balance contributing to these health issues. It is important to note the receptor's relation with other adrenergic receptors such as beta-adrenergic receptors which also play roles in the development or exacerbation of heart and mood disorders. Understanding these receptors can assist in developing antagonists like yohimbine and its derivatives as potential therapeutic agents.
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产品实验方案

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 39:110795 PubMed35545050

2022

Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Dennis A Burke,Veronica A Alvarez

Neuropharmacology 75:47-52 PubMed23851259

2013

FG7142, yohimbine, and βCCE produce anxiogenic-like effects in the elevated plus-maze but do not affect brainstem activated hippocampal theta.

Applications

Unspecified application

Species

Unspecified reactive species

Michelle Yeung,Lily Lu,Adam M Hughes,Dallas Treit,Clayton T Dickson

Journal of neurochemistry 116:984-95 PubMed21143600

2011

β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

John Meitzen,Jessie I Luoma,Christopher M Stern,Paul G Mermelstein
View all publications
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搭配使用产品

Biochemicals

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D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

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Primary Antibodies

AB52642

Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (AB52642)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB138911

ATP-gamma-S, Kinase substrate

Chemical Structure - ATP-gamma-S, Kinase substrate (AB138911)

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