YM298198 hydrochloride，mGlu1拮抗剂(ab120015)
Key features and details
- Potent, selective mGlu1 antagonist
- CAS Number: 1216398-09-2
- Purity: > 99%
Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
YM298198 hydrochloride，mGlu1拮抗剂 -
描述
Potent，selective mGlu1拮抗剂 -
生物学描述
Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic in vivo.
Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration. -
纯度
> 99% -
CAS编号
1216398-09-2 -
化学结构
性能
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化学名称
6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
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分子量
378.92 -
PubChem识别号
45073464 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM
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处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.CN(C1CCCCC1)C(=O)c3sc4nc2ccc(N)cc2n4c3C -
来源
Synthetic
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研究领域
图片
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Chemical Structure - YM298198 hydrochloride, mGlu1 antagonist (ab120015)2D chemical structure image of ab120015, YM298198 hydrochloride, mGlu1 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (6)
ab120015 被引用在 6 文献中.
- Ng AN et al. Amyloid-β1-42 oligomers enhance mGlu5R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling. iScience 26:108412 (2023). PubMed: 38053635
- Biever A et al. PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons. J Neurosci 35:4113-30 (2015). PubMed: 25762659
- Tian J et al. Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Pflugers Arch 466:1301-16 (2014). Mouse . PubMed: 24121765
- Zhang L & Alger BE Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci 30:5724-9 (2010). PubMed: 20410124
- Jo J et al. Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci 13:1216-24 (2010). PubMed: 20852624
- Lafourcade CA et al. Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG. PLoS One 4:e6122 (2009). PubMed: 19568435