YC-1，guanylyl cyclase活化剂(ab120915)
Key features and details
- Reversible soluble guanylyl cyclase activator
- CAS Number: 170632-47-0
- Purity: > 99%
- Soluble in ethanol to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
YC-1，guanylyl cyclase活化剂 -
描述
Reversible soluble guanylyl cyclase活化剂 -
生物学描述
Reversible soluble guanylyl cyclase activator (EC50 = 18.6 μM). NO-independent. Induces a concentration dependent increase in cGMP in vitro. Reduces blood-brain barrier permeability through HIF-1 inhibiton in vivo. -
纯度
> 99% -
CAS编号
170632-47-0 -
化学结构
性能
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化学名称
5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol -
分子量
304.35 -
分子式
C19H16N2O2 -
PubChem识别号
5712 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 50 mM and in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1 -
来源
Synthetic
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研究领域
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
图片
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Chemical Structure - YC-1, guanylyl cyclase activator (ab120915)2D chemical structure image of ab120915, YC-1, guanylyl cyclase activator
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab120915 被引用在 2 文献中.
- Tang S et al. TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair. Front Cell Dev Biol 9:670913 (2021). PubMed: 34178995
- Yang F et al. SDF1-CXCR4 Signaling Maintains Central Post-Stroke Pain through Mediation of Glial-Neuronal Interactions. Front Mol Neurosci 10:226 (2017). PubMed: 28785202