Xestospongin C，IP3 receptor拮抗剂(ab120914)
Key features and details
- Potent, selective, reversible IP3 receptor antagonist
- CAS Number: 88903-69-9
- Purity: > 90%
- Soluble in DMSO to 2 mM and in ethanol to 2 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Xestospongin C，IP3 receptor拮抗剂 -
描述
Potent，selective，reversible IP3 receptor拮抗剂 -
别名
- Araguspongine E
- XeC
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纯度
> 90% -
CAS编号
88903-69-9 -
化学结构
性能
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化学名称
(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine -
分子量
446.72 -
分子式
C28H50N2O2 -
存放说明
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解度概述
Soluble in DMSO to 2 mM and in ethanol to 2 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCC[C@H]2CCCN3CCC(CCCCCCC4CCCN5CCC(CC1)O[C@H]45)O[C@H]23 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Xestospongin C, IP3 receptor antagonist (ab120914)2D chemical structure image of ab120914, Xestospongin C, IP3 receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab120914 被引用在 11 文献中.
- Malek M et al. Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3. J Biol Chem 298:101740 (2022). PubMed: 35182526
- Dulloo I et al. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat Commun 13:1257 (2022). PubMed: 35273168
- Wang J et al. Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3. Biochem Pharmacol 174:113832 (2020). PubMed: 32006470
- Gupta K et al. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials 259:120283 (2020). PubMed: 32827796
- Luo R et al. Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats. FEBS J 286:4356-4373 (2019). PubMed: 31230413