XAV939，Tankyrase抑制剂(ab120897)
Key features and details
- Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling.
- CAS Number: 284028-89-3
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
XAV939，Tankyrase抑制剂 -
描述
Potent tankyrase抑制剂.抑制剂of Wnt/β-catenin signaling. -
纯度
> 98% -
CAS编号
284028-89-3 -
化学结构
性能
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化学名称
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one -
分子量
312.31 -
分子式
C14H11F3N2OS -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC1=NC(C2=CC=C(C(F)(F)F)C=C2)=NC3=C1CSCC3 -
来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120897于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - XAV939, Tankyrase inhibitor (ab120897)2D chemical structure image of ab120897, XAV939, Tankyrase inhibitor
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Immunocytochemistry/ Immunofluorescence - XAV939, Tankyrase inhibitor (ab120897)ab16051 staining ß-catenin in SW480 cells treated with XAV939 (ab120897), by ICC/IF. Increase of ß-catenin cytoplasmic expression and decrease in nuclear expression correlates with increased concentration of XAV939, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120897 (XAV939) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16051 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab120897 被引用在 8 文献中.
- Häfliger J et al. Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity. Cell Mol Gastroenterol Hepatol 15:717-739 (2023). PubMed: 36516930
- Iwatsuki K et al. Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells. Cell Rep Methods 3:100542 (2023). PubMed: 37671016
- Cheng B et al. Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin. Tissue Eng Regen Med 19:823-837 (2022). PubMed: 35467329
- Polley A et al. Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro. Int J Cell Biol 2020:2045969 (2020). PubMed: 32328102
- Du B et al. Long non-coding RNA MALAT1 suppresses the proliferation and migration of endothelial progenitor cells in deep vein thrombosis by regulating the Wnt/ß-catenin pathway. Exp Ther Med 20:3138-3146 (2020). PubMed: 32855682
- Hamidi S et al. Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation. Development 147:N/A (2020). PubMed: 32014865
- Fagnocchi L et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun 7:11903 (2016). PubMed: 27301576
- Lafon-Hughes L et al. VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt. PeerJ 2:e617 (2014). PubMed: 25332845