VU0155041，positive allosteric mGluR4激动剂

关键信息

CAS 号

1093757-42-6

纯度

>99%

形式

Solid

form

分子量

316.2 Da

分子式

C₁₄H₁₅Cl₂NO₃

PubChem

2933724

属性

Synthetic

溶解度

Soluble in 1 eq. NaOH to 100 mM

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

生化试剂名称

2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic Acid

生物学描述

Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection. Available in water-soluble form - please see VU0155041 sodium salt (ab120248).

经典 SMILES

C1CCC(C(C1)C(=O)NC2=CC(=CC(=C2)Cl)Cl)C(=O)O

InChi

InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)

InChiKey

VSMUYYFJVFSVCA-UHFFFAOYSA-N

IUPAC 名

2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid