Vinblastine sulfate，Microtubule dynamics抑制剂
Vinblastine sulfate, Microtubule dynamics inhibitor
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MW 909.1 Da, Purity >95%. Potent microtubule dynamics inhibitor. Inhibits tubulin addition (Ki = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC50 = 1 nM). Antitumor effects in vivo. .
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2810484G07Rik, ALS22, Alpha tubulin, Alpha tubulin isotype M alpha 6, Alpha-tubulin 1, Alpha-tubulin 3, Alpha-tubulin 3E, Alpha-tubulin 6, Alpha-tubulin ubiquitous, B ALPHA 1, Beta 4 tubulin, Beta 5 tubulin, Beta tubulin 1, class VI, Beta-tubulin, Beta2, CDCBM, CDCBM1, CDCBM5, CDCBM6, CFEOM3, CFEOM3A, Class I beta tubulin, Class II beta tubulin isotype, Class IVb beta tubulin, Class VI beta tubulin, Class VIII beta tubulin, DKFZp566F223, Dystonia 4 torsion (autosomal dominant), FEOM3, FLJ25113, FLJ98847, H2 ALPHA, HSA10p15 beta tubulin 4Q, HsT1601, Hum a tub1, Hum a tub2, K-ALPHA-1, LIS3, M(beta)1, M(beta)2, M(beta)3, M(beta)6, M40, MC1-R, MGC117247, MGC16435, MGC171407, MGC55332, MGC8685, M[a]6, Neuron specific beta III Tubulin, Neuron-specific class III beta-tubulin, OK/SW-cl.56, OTTHUMP00000015956, OTTHUMP00000015964, QccE-11995, QccE-15186, RP11-631M21.2, TBA1A_HUMAN, TBA1B_HUMAN, TBA1C_HUMAN, TBA3E_HUMAN, TBA4A_HUMAN, TBB1_HUMAN, TBB2A_HUMAN, TBB2B_HUMAN, TBB3_HUMAN, TBB4B_HUMAN, TBB4_HUMAN, TBB5_HUMAN, TBB6_HUMAN, TBB8_HUMAN, TUBA1, TUBA1A, TUBA1B, TUBA3, TUBA3E, TUBA4A, TUBA6, TUBB, TUBB 1, TUBB 2, TUBB 2A, TUBB 2C, TUBB 4, TUBB PARALOG, TUBB-5, TUBB2B, TUBB4A, TUBB6, TUBB8, Testis-specific alpha-tubulin, Tubb 3, Tubb4b, Tubulin 5 beta, Tubulin B-alpha-1, Tubulin H2-alpha, Tubulin K-alpha-1, Tubulin alpha, Tubulin alpha 1a, Tubulin alpha 3, Tubulin alpha brain specific, Tubulin alpha-1 chain, Tubulin alpha-1A chain, Tubulin alpha-1B chain, Tubulin alpha-1C chain, Tubulin alpha-3 chain, Tubulin alpha-3E chain, Tubulin alpha-4A chain, Tubulin alpha-6 chain, Tubulin alpha-ubiquitous chain, Tubulin beta, Tubulin beta 1 class VI, Tubulin beta 1b, Tubulin beta 2, Tubulin beta 2A, Tubulin beta 2A class IIa, Tubulin beta 2B, Tubulin beta 2B class IIb, Tubulin beta 2C, Tubulin beta 3, Tubulin beta 4, Tubulin beta 4A class IVa, Tubulin beta 5, Tubulin beta 8, Tubulin beta 8 class VIII, Tubulin beta IV, Tubulin beta chain, Tubulin beta class I, Tubulin beta polypeptide, Tubulin beta polypeptide 2, Tubulin beta polypeptide paralog, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-2A chain, Tubulin beta-2B chain, Tubulin beta-2C chain, Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-4B chain, Tubulin beta-5 chain, Tubulin beta-6, Tubulin beta-6 chain, Tubulin beta-8 chain, Tubulin beta-III, Tubulin, alpha 1 (testis specific), Tubulin, alpha 4a, Tubulin, alpha, testis-specific, Tubulin, alpha-1, Tubulin, beta 1, Tubulin, beta, class IVB, Tubulin, beta-4B, bA408E5.3, bA506K6.1, bA631M21.2, bcm948, beta 1 tubulin, beta 2 tubulin, beta 3 tubulin, beta 5, beta Ib tubulin, beta four tubulin, beta-4, class IIa beta-tubulin, class IIb beta-tubulin, class V beta-tubulin, dJ40E16.7, dJ543J19.4, fd02b12, tuba1l, tubulin alpha 1b, tubulin alpha 6, tubulin beta 6 class V, tubulin beta MGC4083, tubulin beta class V, tubulin beta-6 chain-like, tubulin, alpha 1, like, tubulin, alpha 1c, tubulin, alpha 3e, tubulin, alpha, ubiquitous, tubulin, beta 4B class IVb, tubulin, beta, class IIA, tuj 1, wu:fd02b12, zgc:55461
- Chemical Structure
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Chemical Structure - Vinblastine sulfate, Microtubule dynamics inhibitor (AB141475)
2D chemical structure image of ab141475, Vinblastine sulfate, Microtubule dynamics inhibitor
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Biochemicals
AB120507
(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist
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储存信息
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Refer to SDS for further information.
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Tubulin proteins form part of the microtubule complex which is fundamental to cellular processes such as mitosis and intracellular transport. These proteins influence microtubule dynamics important in chromosome segregation and signaling pathways involving cell movement and division. Tubulin interacts with various chemical structures such as vinblastine which affects microtubule polymerization. The dynamic instability of microtubules is important for their role in cell cycle progression and neuronal development.
Pathways
Tubulin family proteins participate in significant pathways like the mitotic spindle assembly and axonal transport. These pathways have implications in the regulation of cell cycle and neuronal functioning. Related proteins within these pathways include kinesins and dyneins which are motor proteins that transport cellular cargo along microtubules. The regulation of these pathways ensures proper cell division and neuronal signaling which are essential for organismal development and homeostasis.
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