Verapamil hydrochloride，L-type Ca2+ channel blocker (ab120140)
Key features and details
- L-type Ca2+ channel blocker
- CAS Number: 152-11-4
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Verapamil hydrochloride，L-type Ca2+ channel blocker -
描述
L-type Ca2+ channel blocker -
生物学描述
L-type Ca2+ channel blocker. Antiarrhythmic in vivo.
Also available in simple stock solutions (ab146680) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
152-11-4 -
化学结构
性能
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化学名称
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride -
分子量
491.06 -
分子式
C27H38N2O4.HCl -
PubChem识别号
62969 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.COc1cc(ccc1OC)C(C#N)(CCCN(C)CCc2ccc(OC)c(OC)c2)C(C)C -
来源
Synthetic
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研究领域
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
图片
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Chemical Structure - Verapamil hydrochloride, L-type Ca2+ channel blocker (ab120140)2D chemical structure image of ab120140, Verapamil hydrochloride, L-type Ca2+ channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120140 被引用在 3 文献中.
- Šrámek J et al. Calcium channel blockers do not protect against saturated fatty acid-induced ER stress and apoptosis in human pancreatic ß-cells. Nutr Metab (Lond) 18:74 (2021). PubMed: 34274001
- Kobuszewska A et al. Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment. SLAS Technol 22:536-546 (2017). PubMed: 28430559
- Silswal N et al. Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction. Am J Physiol Heart Circ Physiol 300:H2016-26 (2011). PubMed: 21421826