UCPH-101，Selective EAAT1抑制剂(ab120309)
Key features and details
- Selective EAAT1 inhibitor
- CAS Number: 1118460-77-7
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
UCPH-101，Selective EAAT1抑制剂 -
描述
Selective EAAT1抑制剂 -
生物学描述
Selective inhibitor of EAAT1 (IC50 = 0.67 μM). Displays >400-fold selectivity over EAAT2 and EAAT3.
Blood-brain barrier permeable analog UCPH-102 also available (ab146404). -
CAS编号
1118460-77-7 -
化学结构
性能
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化学名称
2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile -
分子量
422.48 -
分子式
C27H22N2O3 -
PubChem识别号
25223366 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc(cc1)C2C=3C(=O)CC(CC=3OC(N)=C2C#N)c5cccc4ccccc45 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - UCPH-101, Selective EAAT1 inhibitor (ab120309)2D chemical structure image of ab120309, UCPH-101, Selective EAAT1 inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (7)
ab120309 被引用在 7 文献中.
- Chen C et al. FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer. Breast Cancer Res Treat 201:515-533 (2023). PubMed: 37458908
- Haym I et al. Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102. ChemMedChem N/A:N/A (2016). PubMed: 26797816
- Yang Y & Xu-Friedman MA Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol 113:3634-45 (2015). PubMed: 25855696
- Morioka N et al. Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the a7 nicotinic acetylcholine receptor. Neuroscience 258:374-84 (2014). PubMed: 24300109
- Uwechue NM et al. Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes. J Physiol 590:2317-31 (2012). PubMed: 22411007
- Salvatore MF et al. Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser(19). Exp Neurol 234:428-36 (2012). PubMed: 22285253
- Budisantoso T et al. Mechanisms underlying signal filtering at a multisynapse contact. J Neurosci 32:2357-76 (2012). PubMed: 22396411