JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB146598

Trichostatin A (DMSO solution), histone deacetylase inhibitor

Trichostatin A (DMSO solution), histone deacetylase inhibitor

Be the first to review this product! Submit a review

|

(1 Publication)

MW 302.37 Da, Purity >99%. Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.

查看别名

2810449N18Rik, ABC 35, ABCC 7, AHDC, AHO3, AI043036, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH class 2, ALDH-E1, ALDH-E2, ALDHI, ALDM, ALHDII, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, Abacavir hypersensitivity, susceptibility to, Acetaldehyde dehydrogenase 1, Acetaldehyde dehydrogenase 2, Aldehyde dehydrogenase 1, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase 2 family, Aldehyde dehydrogenase 2 family (mitochondrial), Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase liver cytosolic, Aldehyde dehydrogenase mitochondrial, Aldh, Antigen NY-CO-9, BCD541, BDMR, Beta-interferon, CD142, CD142 antigen, CDA07, CDLS5, CF, CFTR/MRP, CFTR_HUMAN, CPBHM, CTG 26, CTG repeat protein 26, Channel conductance-controlling ATPase, Coagulation factor III, Coagulation factor III (thromboplastin tissue factor), Component of gems 1, Cystic Fibrosis Transmembrane Regulator, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, D10Wsu179e, DKFZP586J0917, DKFZP761B039, DKFZp686H12203, Drug-induced liver injury due to flucloxacillin, EC 3.5.1.98, F3, FLJ16239, FLJ17960, FLJ22237, FLJ35621, FLJ37491, FLJ99588, Fibroblast interferon, GON 10, Gemin-1, HA6116, HD 10, HD 11, HD 2, HD 4, HD 6, HD 7, HD 7B, HD 7a, HD 8, HD 9, HD1, HD3, HD5, HDA10_HUMAN, HDA11_HUMAN, HDAC, HDAC 11, HDAC 7A, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC A, HDAC1_HUMAN, HDAC2_HUMAN, HDAC3_HUMAN, HDAC4_HUMAN, HDAC5_HUMAN, HDAC6_HUMAN, HDAC7_HUMAN, HDAC8_HUMAN, HDAC9_HUMAN, HDACL-1, HDRP, HLA class I histocompatibility antigen, B-13 alpha chain, HLA class I histocompatibility antigen, B-14 alpha chain, HLA class I histocompatibility antigen, B-15 alpha chain, HLA class I histocompatibility antigen, B-18 alpha chain, HLA class I histocompatibility antigen, B-27 alpha chain, HLA class I histocompatibility antigen, B-35 alpha chain, HLA class I histocompatibility antigen, B-37 alpha chain, HLA class I histocompatibility antigen, B-38 alpha chain, HLA class I histocompatibility antigen, B-40 alpha chain, HLA class I histocompatibility antigen, B-41 alpha chain, HLA class I histocompatibility antigen, B-42 alpha chain, HLA class I histocompatibility antigen, B-44 alpha chain, HLA class I histocompatibility antigen, B-45 alpha chain, HLA class I histocompatibility antigen, B-46 alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-48 alpha chain, HLA class I histocompatibility antigen, B-49 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-51 alpha chain, HLA class I histocompatibility antigen, B-52 alpha chain, HLA class I histocompatibility antigen, B-53 alpha chain, HLA class I histocompatibility antigen, B-54 alpha chain, HLA class I histocompatibility antigen, B-55 alpha chain, HLA class I histocompatibility antigen, B-56 alpha chain, HLA class I histocompatibility antigen, B-57 alpha chain, HLA class I histocompatibility antigen, B-58 alpha chain, HLA class I histocompatibility antigen, B-59 alpha chain, HLA class I histocompatibility antigen, B-67 alpha chain, HLA class I histocompatibility antigen, B-7 alpha chain, HLA class I histocompatibility antigen, B-73 alpha chain, HLA class I histocompatibility antigen, B-78 alpha chain, HLA class I histocompatibility antigen, B-8 alpha chain, HLA class I histocompatibility antigen, B-81 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, Histone Deacetylase A, Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 2 (HD2), Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 4/5 related protein, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 6 (HD6), Histone deacetylase 7, Histone deacetylase 7A, Histone deacetylase 7B, Histone deacetylase 8, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase like 1, Histone deacetylase-related protein, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JM 21, KIAA0017, KIAA0288, KIAA0744, KIAA0901, KIAA1047, Liver mitochondrial ALDH, Lymphocyte antigen, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC149722, MGC1806, MGC2318, MGC96956, MHC class I antigen B 7, MITR, MRXS6, Major Histocompatibility Complex Class I B, Mitochondrial aldehyde dehydrogenase 2, Mono ADP ribosyltransferase sirtuin 6, N Cor/SMRT corepressor Rip13, N-CoR, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-6, NCOR1_HUMAN, NCOR2_HUMAN, NY CO 9, Nuclear Receptor Co-Repressor 2, Nuclear receptor corepressor 1, Nucleus encoded mitochondrial aldehyde dehydrogenase 2, OTTHUMP00000017046, OTTHUMP00000028555, OTTHUMP00000032398, OTTHUMP00000125198, OTTHUMP00000197663, OTTHUMP00000202813, OTTHUMP00000202814, OTTHUMP00000223567, OTTHUMP00000223568, OTTHUMP00000224066, OTTHUMP00000226924, OTTHUMP00000227077, OTTHUMP00000227078, PPP1R90, PUMB 1, Pre-mRNA-splicing factor SF3b 130 kDa subunit, Protein phosphatase 1 regulatory subunit 90, RALDH 1, RIP13, RPD 3, RPD3-2, RPD3L1, RSE1, Reduced potassium dependency yeast homolog like 1, Regulatory protein SIR2 homolog, Regulatory protein SIR2 homolog 2, Regulatory protein SIR2 homolog 6, Retinal dehydrogenase 1, Retinaldehyde dehydrogenase 1, Retinoid X receptor interacting protein 13, Rxrip13, SF3B3_HUMAN, SF3b130, SIR2 like 6, SIR2, S. cerevisiae, homolog-loke 2, SIR2-like protein 2, SIR2-like protein 6, SIR2L, SIR2L2, SIR2L6, SIR6_HUMAN, SIRT 2, SIRT2_HUMAN, SMA, SMA 1, SMA 2, SMA 3, SMA 4, SMAP 270, SMAP45, SMN1, SMN2, SMNT, SMN_HUMAN, SMRT, SMRTE, SMRTE tau, STAF130, Silencing Mediator for Retanoid and Thyroid Hormone Receptors, Silencing information regulator 2 like, Silencing mediator of retinoic acid and thyroid hormone receptor, Silent information regulator 2, Sir2 related protein type 2, Sir2 related protein type 6, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), Sirtuin 2, Sirtuin 6, Sirtuin type 2, Sirtuin type 6, Spliceosome-associated protein 130, Splicing factor 3B subunit 3, Splicing factor 3b subunit 3 130kD, Survival motor neuron protein, Survival of motor neuron 1, telomeric, Synovitis, chronic, susceptibility to, T-BCD541, T3 receptor-associating factor, TFA, TF_HUMAN, TNR CFTR, TNRC 14, TRAC 1, Thromboplastin, Thyroid retinoic acid receptor associated corepressor, Thyroid-, Tissue factor, WTS, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, cAMP-dependent chloride channel, dJ760C5.1, hN CoR, leukocyte antigen class I-B, retinoic-acid-receptor-associated corepressor, thyroid hormone and retinoic acid receptor associated corepressor 1, transcriptional regulator homolog RPD3

1 Images
Chemical Structure - Trichostatin A (DMSO solution), histone deacetylase inhibitor (AB146598)
  • Chemical Structure

Lab

Chemical Structure - Trichostatin A (DMSO solution), histone deacetylase inhibitor (AB146598)

2D chemical structure image of ab146598, Trichostatin A (DMSO solution), histone deacetylase inhibitor

关键信息

CAS 号

58880-19-6

纯度

>99%

形式

Liquid

form

分子量

302.37 Da

分子式

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>2</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

444732

属性

Synthetic

生化试剂名称

trichostatin A

生物学描述

Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.

经典 SMILES

CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

同分异构的 SMILES

C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

InChi

InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChiKey

RTKIYFITIVXBLE-QEQCGCAPSA-N

IUPAC 名

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

产品实验方案

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e32553 PubMed39183840

2024

Effects of EZH2 inhibitor, trichostatin A, and 5-azacytidine combinatorial treatment on osteogenic differentiation of dental pulp stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Edit Hrubi,László Imre,Csaba Hegedüs
View all publications

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂,为您科研的每一步提供支持。若我们的产品未能达到预期性能,我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com