AB145522

TPCA 1, IkappaB kinase inhibitor

Name: TPCA 1, IkappaB kinase抑制剂 (ab145522)| Abcam中文官网
Brand: Abcam Limited
SKU: AB145522
Price: 2181 CNY
Availability: InStock

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(4 Publications)

MW 279.29 Da, Purity >98%. Potent, selective IκB kinase inhibitor (IC₅₀ = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo. .

查看别名

I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-beta, IKK2, IKKB_HUMAN, IMD15, IkBKB, Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta

1 Images

Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

Chemical Structure

Lab

Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

2D chemical structure image of ab145522, TPCA 1, IkappaB kinase inhibitor

关键信息

CAS 号

507475-17-4

纯度

>98%

形式

Solid

form

分子量

279.29 Da

分子式

C12H10FN3O2S

PubChem

9903786

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生化试剂名称

5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide

生物学描述

Potent, selective IκB kinase inhibitor (IC₅₀ = 17.9 nM). Inhibits NF-κB nuclear localization. Shows anti-inflammatory effects in vivo.

经典 SMILES

C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

InChi

InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

InChiKey

SAYGKHKXGCPTLX-UHFFFAOYSA-N

IUPAC 名

2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

European heart journal open 5:oeaf011 PubMed40201592

2025

Modulation of cell fate by shock wave therapy in ischaemic heart disease.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Graber,Can Gollmann-Tepeköylü,Victor Schweiger,Jakob Hirsch,Leo Pölzl,Felix Nägele,Daniela Lener,Hubert Hackl,Sieghart Sopper,Elke Kirchmair,Sophia Mair,Jakob Voelkl,Christina Plattner,Felix Eichin,Zlatko Trajanoski,Anne Krogsdam,Jonas Eder,Manuel Fiegl,Dominik Hau,Ivan Tancevski,Michael Grimm,John P Cooke,Johannes Holfeld

Nature 617:827-834 PubMed37165186

2023

EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.

Applications

Unspecified application

Species

Unspecified reactive species

Sevval Nur Bilgic,Aylin Domaniku,Batu Toledo,Samet Agca,Bahar Z C Weber,Dilsad H Arabaci,Zeynep Ozornek,Pascale Lause,Jean-Paul Thissen,Audrey Loumaye,Serkan Kir

The Journal of experimental medicine 219: PubMed36098746

2022

Induction of natural IgE by glucocorticoids.

Applications

Unspecified application

Species

Unspecified reactive species

Jaechul Lim,Erica V Lin,Jun Young Hong,Bharat Vaidyanathan,Steven A Erickson,Charles Annicelli,Ruslan Medzhitov

Reproduction (Cambridge, England) 159:503-511 PubMed32103820

2020

IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle.

Applications

Unspecified application

Species

Unspecified reactive species

Keigo Nakamura,Kazuya Kusama,Atsushi Ideta,Kazuhiko Imakawa,Masatoshi Hori

View all publications

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TPCA 1, IkappaB kinase inhibitor