Tiagabine hydrochloride，GAT-1抑制剂(ab120237)
Key features and details
- Selective GAT-1 inhibitor
- CAS Number: 145821-59-6
- Purity: > 99%
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Tiagabine hydrochloride，GAT-1抑制剂 -
描述
Selective GAT-1抑制剂 -
别名
- Gabitril
- NNC 05-328
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生物学描述
GABA uptake inhibitor, selective for GAT-1. Anticonvulsant in vivo.
Also available in simple stock solutions (ab146701) - add 1 ml of water to get an exact, ready-to-use concentration. -
纯度
> 99% -
CAS编号
145821-59-6 -
化学结构
性能
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化学名称
(3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride -
分子量
412.00 -
分子式
C20H25NO2S2.HCl -
PubChem识别号
91274 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cc3ccsc3C(=CCCN1CCC[C@H](C1)C(=O)O)c2sccc2C -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Tiagabine hydrochloride, GAT-1 inhibitor (ab120237)2D chemical structure image of ab120237, Tiagabine hydrochloride, GAT-1 inhibitor
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Functional Studies - Tiagabine hydrochloride, GAT-1 inhibitor (ab120237)Rideau Batista Novais et al PLoS One. 2014 Sep 3;9(9):e106302. doi: 10.1371/journal.pone.0106302. eCollection 2014. Fig 4. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Tiagabine restored LTD via the activation of GABAB receptors in LPS animals.
Tiagabine (20 µM) and/or CGP55845 (1 µM) were applied in the perfusate during both the recording of baseline activity and LFS (1 Hz stimulation, 15 min) delivery. (Panel A) Time-course and recapitulative graph depicting LTD induction in control (SAL) animals. LFS induced an LTD of fEPSP amplitude in control animals (SAL; filled circles; N = 8), which was significantly blocked by the GABAB receptor antagonist CGP55845 (SAL+CGP; open circles; N = 5; * p<0.05 vs SAL group). Tiagabine had no significant effect on LTD level (SAL+T; filled triangles; N = 8).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120237 被引用在 2 文献中.
- Rideau Batista Novais A et al. Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation. PLoS One 9:e106302 (2014). PubMed: 25184226
- Raccuglia D & Mueller U Focal uncaging of GABA reveals a temporally defined role for GABAergic inhibition during appetitive associative olfactory conditioning in honeybees. Learn Mem 20:410-6 (2013). PubMed: 23860600