Thioperamide maleate，H3拮抗剂(ab120021)
Key features and details
- Potent, selective H3 antagonist
- CAS Number: 148440-81-7
Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Thioperamide maleate，H3拮抗剂 -
描述
Potent，selective H3拮抗剂 -
生物学描述
Potent, selective H3 antagonist that crosses the blood-brain barrier.
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CAS编号
148440-81-7 -
化学结构
性能
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化学名称
N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide maleate
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分子量
408.51 -
分子式
C15H24N4S.C4H4O4 -
PubChem识别号
11211984 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 50 mM
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处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
S=C(NC1CCCCC1)N2CCC(CC2)c3cncn3.O=C(O)/C=CC(=O)O -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Thioperamide maleate, H3 antagonist (ab120021)2D chemical structure image of ab120021, Thioperamide maleate, H3 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (5)
ab120021 被引用在 5 文献中.
- Wang N et al. Histamine H3 Receptor Antagonist Enhances Neurogenesis and Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments. Front Pharmacol 10:1583 (2019). PubMed: 32038255
- Olszewska B et al. 4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H3 Receptor Antagonist: Further Structure?Activity Relationship Exploration and In Vitro and In Vivo Pharmacological Evaluation. Int J Mol Sci 19:N/A (2018). PubMed: 29671795
- Zhou X et al. Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System. Front Pharmacol 8:852 (2017). PubMed: 29213238
- Frandsen IO et al. Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. Sci Rep 7:4829 (2017). PubMed: 28684785
- Masini D et al. The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism. Transl Psychiatry 7:e1088 (2017). PubMed: 28398338