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AB235551

Teneligliptin，DPP-4抑制剂

Teneligliptin, DPP-4 inhibitor

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(1 Publication)

MW 426.6 Da, Purity >98%. Potent, long-lasting DPP-4 (dipeptidylpeptidase-4) inhibitor. Competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro (IC50 = ~ 1 nM). Attenuates lipogenesis in the liver by activating AMPK and downregulating the expression of genes involved in lipogenesis. Improves metabolic abnormalities in a mouse model of postmenopausal obesity.

查看别名

ADA-binding protein, ADABP, ADCP-2, Adenosine deaminase complexing protein 2, CD 26, CD26 antigen, CD26 antigen 3, DPP IV, DPP IV estoenzyme, DPP4_HUMAN, Dipeptidyl peptidase 4, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase, intestinal, Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), Intestinal dipeptidyl peptidase, T-cell activation antigen CD26, TP 103

关键信息

CAS 号

760937-92-6

纯度

>98%

形式

Solid

form

分子量

426.6 Da

分子式

C<sub>2</sub><sub>2</sub>H<sub>3</sub><sub>0</sub>N<sub>6</sub>OS

PubChem

11949652

属性

Synthetic

溶解度

Soluble in water to 159.01 mM

Soluble in DMSO to 159.01 mM

Soluble in ethanol to 27.03 mM

生化试剂名称

Teneligliptin

生物学描述

Potent, long-lasting DPP-4 (dipeptidylpeptidase-4) inhibitor. Competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro (IC50 = ~ 1 nM). Attenuates lipogenesis in the liver by activating AMPK and downregulating the expression of genes involved in lipogenesis. Improves metabolic abnormalities in a mouse model of postmenopausal obesity.

经典 SMILES

CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5

同分异构的 SMILES

CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5

InChi

InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1

InChiKey

WGRQANOPCQRCME-PMACEKPBSA-N

IUPAC 名

[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone

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搭配使用产品

Biochemicals

AB142171

NVP DPP 728, DPP-IV inhibitor

Chemical Structure - NVP DPP 728, DPP-IV inhibitor (AB142171)

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Biochemicals

AB141724

P32/98, dipeptidyl peptidase IV (DPP4) inhibitor

Chemical Structure - P32/98, dipeptidyl peptidase IV (DPP4) inhibitor (AB141724)

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Biochemicals

AB144783

N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin

Chemical Structure - N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin (AB144783)

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Reagents, Controls & Accessories

AB64226

Protein Block

Immunocytochemistry - Protein Block (AB64226)

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产品详情

This product is manufactured by BioVision, an Abcam company and was previously called B1932 Teneligliptin. B1932-50 is the same size as the 50 mg size of ab235551.
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Store in the dark|Store under desiccating conditions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Dipeptidyl peptidase 4 also known as DPP4 or CD26 functions as a serine exopeptidase. This enzyme is involved in cleaving dipeptides from the N-terminus of polypeptides. DPP4 with a mass of approximately 110 kDa is expressed in various tissues such as the liver intestines kidney and lymphocytes. It exists in both a membrane-bound form and a soluble form in blood plasma.
Biological function summary

DPP4 plays a significant role in glucose metabolism and immune function. The enzyme interacts with members of the immune system and regulates proteins such as chemokines growth factors and neuropeptides. DPP4 acts independently and is not known to be part of a larger complex. It modulates biological processes by inactivating peptide hormones and signaling molecules which impacts glucose homeostasis and immune responses.

Pathways

DPP4 impacts the incretin signaling pathway and the immune response pathway. Incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are substrates of DPP4 and play important roles in glucose metabolism. DPP4 also interacts with proteins such as adenosine deaminase (ADA) which impacts T-cell function and immune regulation. The regulation of these pathways by DPP4 influences metabolic and immune health.

DPP4 involvement is relevant in type 2 diabetes and immunological disorders. In type 2 diabetes DPP4 inhibitors modulate the incretin hormones improving glycemic control. Proteins like GLP-1 are affected by DPP4 activity connecting it to diabetes management. In autoimmune diseases altered DPP4 expression can impact immune cell functions influencing conditions such as rheumatoid arthritis. Through its effects on ADA and associated pathways DPP4 can influence both metabolic and immune-related disorders.
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产品实验方案

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Diabetes, metabolic syndrome and obesity : targets 12:2289-2302 PubMed31807042

2019

Essential Role Of High Glucose-Induced Overexpression Of PKCβ And PKCδ In GLP-1 Resistance In Rodent Cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xietian Pan,Jiangwei Chen,Tingting Wang,Mingming Zhang,Haichang Wang,Haokao Gao
View all publications
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Abcam Product Promise

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