Telmisartan，angiotensin II (AT1)拮抗剂(ab120831)
Key features and details
- Selective angiotensin II (AT1) antagonist
- CAS Number: 144701-48-4
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Telmisartan，angiotensin II (AT1)拮抗剂 -
描述
Selective angiotensin II (AT1)拮抗剂 -
生物学描述
Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.
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纯度
> 99% -
CAS编号
144701-48-4 -
化学结构
性能
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化学名称
4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid -
分子量
514.63 -
分子式
C33H30N4O2 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
相关产品
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120831于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (ab120831)2D chemical structure image of ab120831, Telmisartan, angiotensin II (AT1) antagonist
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Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (ab120831)ab8934 staining PPARα in serum starved HepG2 cells treated with telmisartan (ab120831), by ICC/IF. Increase in PPARα expression correlates with increased concentration of telmisartan, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120831 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab8934 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120831 被引用在 1 文献中.
- Zhang X et al. Telmisartan Mitigates TNF-a-Induced Type II Collagen Reduction by Upregulating SOX-9. ACS Omega 6:11756-11761 (2021). PubMed: 34056329