AB120831

Telmisartan, angiotensin II (AT1) antagonist

Name: Telmisartan, angiotensin II (AT1)拮抗剂 (ab120831)| Abcam中文官网
Brand: Abcam Limited
SKU: AB120831
Price: 1516 CNY
Availability: InStock

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(1 Publication)

MW 514.63 g/mol, Purity >99%. Selective AT₁ receptor antagonist (K_i = 3.7 nM). Partial PPAR-γ agonist.

2 Images

Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (AB120831)

FuncS

Unknown

Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (AB120831)

ab8934 staining PPARα in serum starved HepG2 cells treated with telmisartan (ab120831), by ICC/IF. Increase in PPARα expression correlates with increased concentration of telmisartan, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120831 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab8934 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight^® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (AB120831)

Chemical Structure

Lab

Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (AB120831)

2D chemical structure image of ab120831, Telmisartan, angiotensin II (AT1) antagonist

关键信息

CAS 号

144701-48-4

纯度

>99%

形式

Solid

form

分子量

514.63 g/mol

属性

Synthetic

溶解度

Soluble in DMSO to 10 mM

生物学描述

Selective AT₁ receptor antagonist (K_i = 3.7 nM) . Partial PPAR-γ agonist.

IUPAC 名

4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

The product can be stored for up to 12 months

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产品实验方案

Visit the General protocols
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

ACS omega 6:11756-11761 PubMed34056329

2021

Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuying Zhang,Yanfeng Dong,Hanyu Dong,Yanhui Cui,Qing Du,Xiaoli Wang,Lanlan Li,Hongju Zhang

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Telmisartan, angiotensin II (AT1) antagonist