Src Kinase抑制剂I (SKI-1)
Src Kinase Inhibitor I (SKI-1)
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(6 Publications)
MW 373.4 Da, Purity >98%. Potent, selective and dual site Src family tyrosine kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck, respectively). Cell-permeable, reversible and ATP-competitive. Interacts with both ATP and peptide-binding sites. Additionally inhibits VEGFR2 and C-fms (IC50 values are 0.32 and 30 μM, respectively). Induces apoptosis.
查看别名
CARD 3, CARD carrying kinase, CARD containing ICE associated kinase, CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase, CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARDIAK, CLARP kinase, GIG 30, Growth inhibiting gene 30, RICK, RIP-like-interacting CLARP kinase, RIPK2_HUMAN, Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase, Receptor interacting serine threonine kinase 2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2, TNFRSF, Tyrosine-protein kinase RIPK2, UNQ277/PRO314/PRO34092
- FuncS
Unknown
Functional Studies - Src Kinase Inhibitor I (SKI-1) (AB120839)
ab11512 staining E cadherin in SW480 cells treated with Src Kinase Inhibitor I (SKI-1) (ab120839), by ICC/IF. Increase of E cadherin expression correlates with increased concentration of Src Kinase Inhibitor I (SKI-1), as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120839 (Src Kinase Inhibitor I (SKI-1)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab11512 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rat polyclonal antibody (ab98386) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
- Chemical Structure
Lab
Chemical Structure - Src Kinase Inhibitor I (SKI-1) (AB120839)
2D chemical structure image of ab120839, Src Kinase Inhibitor I (SKI-1)
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储存信息
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Refer to SDS for further information.
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RIP2 interacts with key components of the immune signaling network. It forms part of a complex with other proteins like nucleotide-binding oligomerization domain (NOD) proteins influencing immune responses. By binding to NOD1 and NOD2 RIP2 modulates inflammatory signaling pathways leading to the activation of NF-kB and the production of inflammatory cytokines. This protein helps regulate the body's defense against bacterial infections and influences inflammation processes.
Pathways
RIP2 plays an integral role in the NOD-like receptor signaling pathway and is also involved in toll-like receptor signaling. In its pathways RIP2 interacts closely with proteins like IKK complexes and the Tak1 complex orchestrating signaling cascades leading to the activation of NF-kB and MAPK pathways. These pathways are essential for instigating the immune response and managing inflammatory signals highlighting how RIP2 acts as a pivotal mediator in these biological routes.
文献 (6)
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Cell reports 24:987-1000.e7 PubMed30044993
2018
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PloS one 12:e0188645 PubMed29190738
2017
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Journal of immunology (Baltimore, Md. : 1950) 199:3261-3269 PubMed28954885
2017
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Cell adhesion & migration 12:286-298 PubMed28678601
2017
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Journal of medical virology 89:1852-1860 PubMed28480962
2017
Applications
BL
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Human
Cell death and differentiation 23:1749-1764 PubMed27518433
2016
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Unspecified application
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Unspecified reactive species
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