SP600125，JNK抑制剂(ab120065)
Key features and details
- JNK inhibitor
- CAS Number: 129-56-6
- Soluble in DMSO to 100 mM and in ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
SP600125，JNK抑制剂 -
描述
JNK抑制剂 -
生物学描述
Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
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CAS编号
129-56-6 -
化学结构
性能
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化学名称
1,9-Pyrazoloanthrone -
分子量
220.23 -
分子式
C14H8N2O -
PubChem识别号
8515 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 5 mM (with heating) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C4c1cccc2nnc(c12)c3ccccc34 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - SP600125, JNK inhibitor (ab120065)2D chemical structure image of ab120065, SP600125, JNK inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (39)
ab120065 被引用在 39 文献中.
- Gao S et al. Effects of Holliday Junction-Recognition Protein-Mediated C-Jun N-Terminal Kinase/ Signal Transducer and Activator of Transcription 3 Signaling Pathway on Cell Proliferation, Cell Cycle and Cell Apoptosis in Bladder Urothelial Carcinoma. Tohoku J Exp Med 259:209-219 (2023). PubMed: 36543245
- Zhang L et al. Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect. PLoS Pathog 19:e1011134 (2023). PubMed: 36706154
- Wang G et al. Exenatide exerts a neuroprotective effect against diabetic cognitive impairment in rats by inhibiting apoptosis: Role of the JNK/c-JUN signaling pathway. Mol Med Rep 25:N/A (2022). PubMed: 35119079
- Hu X et al. Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis. Front Physiol 13:823275 (2022). PubMed: 35211032
- Ivshina MP et al. CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia. Glia 70:1850-1863 (2022). PubMed: 35635122