Sorafenib，multikinase抑制剂

关键信息

CAS 号

284461-73-0

纯度

>98%

形式

Solid

form

分子量

464.8 Da

分子式

C₂₁H₁₆ClF₃N₄O₃

PubChem

216239

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生化试剂名称

Sorafenib

生物学描述

Potent multikinase inhibitor that targets the RAF/MEK/ERK pathway in tumor cells, and tyrosine kinases involved in tumor angiogenesis, oncogenesis, and maintenance of the tumor microenvironment. Inhibits Raf-1, B-Raf, VEGFR-2, VEGFR-3, PDGFR-β, Flt3, c-KIT and FGFR-1 (IC₅₀ values are 6 nM, 22 nM, 90 nM, 20 nM, 57 nM, 58 nM, 68 nM and 580 nM in cell-free assays, respectively).

经典 SMILES

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChi

InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChiKey

MLDQJTXFUGDVEO-UHFFFAOYSA-N

IUPAC 名

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide