Sodium salicylate，anti-inflammatory agent (ab120746)
Key features and details
- Cell-permeable anti-inflammatory agent
- CAS Number: 54-21-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Sodium salicylate，anti-inflammatory agent -
描述
Cell-permeable anti-inflammatory agent -
生物学描述
Cell-permeable anti-inflammatory agent. Inhibits cyclooxygenases preventing prostaglandin formation. Inhibits components of the MAPK cascade, NF-κB and AP-1. Induces apoptosis through p38 MAPK activation.
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纯度
> 99% -
CAS编号
54-21-7 -
化学结构
性能
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化学名称
2-Hydroxybenzoic acid sodium salt -
分子量
160.10 -
分子式
C7H5NaO3 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120746于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
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Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Sodium salicylate, anti-inflammatory agent (ab120746)2D chemical structure image of ab120746, Sodium salicylate, anti-inflammatory agent
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Functional Studies - Sodium salicylate, anti-inflammatory agent (ab120746)THP1 cells were incubated at 37°C for 40h with vehicle control (0 µM) and different concentrations of sodium salicylate (ab120746). Decreased expression of scavenging receptor SR-BI (ab52629) in THP1 cells correlates with an increase in sodium salicylate concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab52629 at 1/2000 dilution and ab8227 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120746 被引用在 1 文献中.
- Pritchard R et al. Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway. Biochem Pharmacol 154:318-334 (2018). PubMed: 29800556