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AB145053

SC 221409，Cdk2抑制剂

SC 221409, Cdk2 inhibitor

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(1 Publication)

MW 395.23 g/mol, Purity >97%. Potent, selective, ATP-competitive Cdk2 inhibitor (IC50 = 60 nM). Cell-permeable.
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Chemical Structure - SC 221409, Cdk2 inhibitor (AB145053)
  • Chemical Structure

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Chemical Structure - SC 221409, Cdk2 inhibitor (AB145053)

2D chemical structure image of ab145053, SC 221409, Cdk2 inhibitor

关键信息

CAS 号

222035-13-4

纯度

>97%

形式

Solid

form

分子量

395.23 g/mol

分子式

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>1</sub>BrN<sub>4</sub>O<sub>3</sub>S

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生物学描述

Potent, selective, ATP-competitive Cdk2 inhibitor (IC50 = 60 nM). Cell-permeable.

同分异构的 SMILES

NS(=O)(=O)C1CCC(CC1)N\N=C2\C3CC(BR)CCC3NC2=O

InChi

InChI=1S/C14H11BrN4O3S/c15-8-1-6-12-11(7-8)13(14(20)17-12)19-18-9-2-4-10(5-3-9)23(16,21)22/h1-7,18H,(H2,16,21,22)(H,17,19,20)

InChiKey

ODZNNZYRBRRREX-UHFFFAOYSA-N

IUPAC 名

4-[2-(5-Bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]benzenesulfonamide

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搭配使用产品

Biochemicals

AB120767

Dexmedetomidine hydrochloride, alpha2 agonist

Chemical Structure - Dexmedetomidine hydrochloride, alpha2 agonist (AB120767)

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Biochemicals

AB285379

Apremilast

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Biochemicals

AB141494

PKC412, Broad spectrum protein kinase inhibitor

Chemical Structure - PKC412, Broad spectrum protein kinase inhibitor (AB141494)

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Biochemicals

AB120152

AF-DX 116 (Otenzepad), M2 antagonist

Chemical Structure - AF-DX 116 (Otenzepad), M2 antagonist (AB120152)

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Store under desiccating conditions
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产品实验方案

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:3696 PubMed35760790

2022

G1/S restriction point coordinates phasic gene expression and cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Brian DeVeale,Leqian Liu,Ryan Boileau,Jennifer Swindlehurst-Chan,Bryan Marsh,Jacob W Freimer,Adam Abate,Robert Blelloch
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