(S)-(+)-Rolipram，PDE4抑制剂
(S)-(+)-Rolipram, PDE4 inhibitor
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(1 Publication)
MW 275.34 Da, Purity >99%. PDE4 inhibitor (IC50 = 0.58 μM). Less active enantiomer. Achieve your results faster with highly validated, pure and trusted compounds.
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2EL, 5''-cyclic phosphodiesterase 4A, 5''-cyclic phosphodiesterase 4B, 5''-cyclic phosphodiesterase 4C, 5''-cyclic phosphodiesterase 4D, DKFZp686F2182, DKFZp686M11213, DPDE 1, DPDE2, DPDE3, DPDE4, Dunce like phosphodiesterase E3, FLJ97311, HSPDE4D, MGC126222, MGC126529, OTTHUMP00000010652, OTTHUMP00000010653, OTTHUMP00000010654, OTTHUMP00000010656, OTTHUMP00000232365, PDE 21, PDE IVB, PDE32, PDE4, PDE43, PDE46, PDE4A11, PDE4A_HUMAN, PDE4B5, PDE4B_HUMAN, PDE4C_HUMAN, PDE4DN2, PDE4D_HUMAN, Phosphodiesterase 4A, Phosphodiesterase 4A, cAMP-specific (dunce, Phosphodiesterase 4B, Phosphodiesterase 4B cAMP specific, Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila), Phosphodiesterase 4C, Phosphodiesterase 4C cAMP specific, Phosphodiesterase 4C, cAMP specific (phosphodiesterase E1 dunce homolog, Drosophila), Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3), Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila), Phosphodiesterase 4D cAMP-specific, Phosphodiesterase 4D, cAMP specific (dunce), Phosphodiesterase E1 dunce homolog, Phosphodiesterase E1 dunce homolog Drosophila, Phosphodiesterase E2 dunce homolog, Drosophila, Phosphodiesterase type 4C, STRK1, cAMP specific 3' 5' cyclic phosphodiesterase 4C, cAMP specific 3',5' cyclic phosphodiesterase 4D, cAMP specific phosphodiesterase, cAMP specific phosphodiesterase 4D, cAMP specific phosphodiesterase PDE4D6, cAMP-specific 3'', cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific phosphodiesterase-4 B isoform, dunce like phosphodiesterase E2, dunce-like phosphodiesterase E4, phosphodiesterase 4A cAMP specific, phosphodiesterase E2 dunce homolog, phosphodiesterase isozyme 4, phosphodiesterase type 4A11
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Chemical Structure - (S)-(+)-Rolipram, PDE4 inhibitor (AB120030)
2D chemical structure image of ab120030, (S)-(+)-Rolipram, PDE4 inhibitor
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These PDE4 enzymes serve critical functions in modulating cellular responses to extracellular signals. By regulating cAMP levels they influence processes such as inflammation and smooth muscle contraction. PDE4 enzymes do not typically form part of large protein complexes but may interact with other proteins such as signaling scaffolds. Their ability to regulate cAMP a second messenger makes them important players in cellular signaling pathways. Each PDE4 subtype plays specialized roles depending on their expression patterns and local cellular environments.
Pathways
PDE4 enzymes critically impact the regulation of the cAMP signaling pathway and the MAPK/ERK pathway. cAMP is a pivotal signaling molecule in transferring hormonal signals into cellular responses. PDE4 enzymes modulate intracellular cAMP levels affecting processes like activation of protein kinase A (PKA) and cAMP-response element-binding protein (CREB). Relation exists between PDE4 and other proteins like EPAC which also bind cAMP to elicit distinct cellular responses. The modulation of MAPK/ERK pathway by PDE4 enzymes further integrates them into the wider network of cellular signal transduction.
文献 (1)
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OBM neurobiology 5: PubMed33521586
2021
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