Ryanodine，Ca2+ release modulator (ab120083)
Key features and details
- Ca2+ release modulator
- CAS Number: 15662-33-6
- Soluble in ethanol to 10 mM
- Form / State: Solid
- Source: Ryania speciosa
概述
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产品名称
Ryanodine，Ca2+ release modulator -
描述
Ca2+ release modulator -
生物学描述
Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.
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CAS编号
15662-33-6 -
化学结构
性能
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化学名称
1H-Pyrrole-2-carboxylic acid (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2] pentaleno[1,6-bc]furan-8-yl ester -
分子量
493.55 -
分子式
C25H35NO9 -
PubChem识别号
5114 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)[C@@]6(O)C(OC(=O)c1cccn1)[C@]2(O)[C@@]5(O)[C@@]34O[C@@](O)(C[C@@]2(C)[C@@]4(O)CC[C@H](C)[C@H]3O)[C@]56C -
来源
Ryania speciosa
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研究领域
图片
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Chemical Structure - Ryanodine, Ca2+ release modulator (ab120083)2D chemical structure image of ab120083, Ryanodine, Ca2+ release modulator
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Functional Studies - Ryanodine, Ca2+ release modulator (ab120083)Image from Touchberry CD et al., J Biol Chem. 2010;285(51):40312-21. Fig 4(A-B).; doi: 10.1074/jbc.M110.179689.Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (37)
ab120083 被引用在 37 文献中.
- Wei K et al. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther 8:22 (2023). PubMed: 36658134
- King CM et al. Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals. Cell Rep 30:3466-3477.e4 (2020). PubMed: 32160550
- Sahu G et al. Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability. Cell Rep 28:2427-2442.e6 (2019). PubMed: 31461656
- Chen T et al. ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury. Neuroscience 416:268-280 (2019). PubMed: 31425734
- Luo R et al. Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats. FEBS J 286:4356-4373 (2019). PubMed: 31230413