AB120264

Ruthenium red, Ca2+ signaling inhibitor

Name: Ruthenium red, Ca2+ signaling抑制剂 (ab120264)| Abcam中文官网
Brand: Abcam Limited
SKU: AB120264
Price: 774 CNY
Availability: InStock

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(7 Publications)

MW 790.4 Da. Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels.

1 Images

Chemical Structure - Ruthenium red, Ca2+ signaling inhibitor (AB120264)

Chemical Structure

Lab

Chemical Structure - Ruthenium red, Ca2+ signaling inhibitor (AB120264)

2D chemical structure image of ab120264, Ruthenium red, Ca2+ signaling inhibitor

关键信息

形式

Solid

form

分子量

790.4 Da

分子式

Cl6H46N14O2Ru3

PubChem

16218584

属性

Synthetic

溶解度

Soluble in water to 10 mM

生化试剂名称

Ammoniated ruthenium oxychloride

生物学描述

Ca2+ signaling inhibitor. Inhibits mitochondrial Ca2+ uniporter, Ca2+-ATPase, troponin C and calmodulin. Blocks intracellular Ca2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening. Inhibits Ca2+-induced Ca2+ release from ryanodine-sensitive intracellular Ca2+ stores. Blocks large-conductance Ca2+-activated potassium channels

经典 SMILES

N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]

InChi

InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6

InChiKey

JQJSTVUROJELSR-UHFFFAOYSA-H

IUPAC 名

azane;ruthenium(2+);hexachloride;dihydrate

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:6751 PubMed38514795

2024

MCU-independent Ca uptake mediates mitochondrial Ca overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J Bround,Eaman Abay,Jiuzhou Huo,Julian R Havens,Allen J York,Donald M Bers,Jeffery D Molkentin

Antioxidants (Basel, Switzerland) 11: PubMed35052675

2022

Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function.

Applications

Unspecified application

Species

Unspecified reactive species

Jisoo Song,Gwonhwa Song,Sunwoo Park,Whasun Lim

Pesticide biochemistry and physiology 163:84-93 PubMed31973874

2020

Ivermectin-induced programmed cell death and disruption of mitochondrial membrane potential in bovine mammary gland epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hahyun Park,Gwonhwa Song,Whasun Lim

Carbohydrate polymers 225:115236 PubMed31521274

2019

Dextran as an elicitor of phenylpropanoid and flavonoid biosynthesis in tomato fruit against gray mold infection.

Applications

Unspecified application

Species

Unspecified reactive species

Laifeng Lu,Lifeng Ji,Ruixi Shi,Shuhua Li,Xi Zhang,Qingbin Guo,Changlu Wang,Liping Qiao

Molecular cell 67:711-723.e7 PubMed28820965

2017

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening.

Applications

Unspecified application

Species

Unspecified reactive species

Daniela M Arduino,Jennifer Wettmarshausen,Horia Vais,Paloma Navas-Navarro,Yiming Cheng,Anja Leimpek,Zhongming Ma,Alba Delrio-Lorenzo,Andrea Giordano,Cecilia Garcia-Perez,Guillaume Médard,Bernhard Kuster,Javier García-Sancho,Dejana Mokranjac,J Kevin Foskett,M Teresa Alonso,Fabiana Perocchi

PloS one 12:e0172491 PubMed28273117

2017

Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Lea Weber,Klaudia Al-Refae,Juliane Ebbert,Peter Jägers,Janine Altmüller,Christian Becker,Stephan Hahn,Günter Gisselmann,Hanns Hatt

The Journal of neuroscience : the official journal of the Society for Neuroscience 31:7089-101 PubMed21562271

2011

The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel A Ryskamp,Paul Witkovsky,Peter Barabas,Wei Huang,Christopher Koehler,Nikolay P Akimov,Suk Hee Lee,Shiwani Chauhan,Wei Xing,René C Rentería,Wolfgang Liedtke,David Krizaj

View all publications

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Ruthenium red, Ca2+ signaling inhibitor