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AB142129

(R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor

(R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor

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(1 Publication)

MW 259.26 Da, Purity >98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.

查看别名

2610203G15Rik, 2900045O07Rik, AF229032, AIO, AW108261, Aiolos, CLL associated antigen KW 6, CRBN_HUMAN, Cereblon, DKFZp781K0715, DNA-binding protein Ikaros, Hs.54452, IK1, IKAROS, IKAROS family zinc finger 1 (Ikaros), IKAROS family zinc finger 3, IKAROS family zinc finger 3 (Aiolos), IKZF1_HUMAN, IKZF3_HUMAN, Ikaros (zinc finger protein), Ikaros family zinc finger protein 1, Ikaros family zinc finger protein 3, LYF1, Lymphoid transcription factor LyF-1, MGC27358, MRT2A, OTTHUMP00000209555, PRO0758, Protein cereblon, Protein x 0001, ZNFN1A1, ZNFN1A3, Zinc finger protein Aiolos, Zinc finger protein subfamily 1A 1, Zinc finger protein subfamily 1A 1 (Ikaros), Zinc finger protein subfamily 1A 3, Zinc finger protein subfamily 1A 3 (Aiolos), Zinc finger protein subfamily 1A, member 3, Zinc finger protein, subfamily 1A, member 1, hIk 1, piL, zinc finger DNA binding protein Aiolos

1 Images
Chemical Structure - (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor (AB142129)
  • Chemical Structure

Lab

Chemical Structure - (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor (AB142129)

2D chemical structure image of ab142129, (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor

关键信息

CAS 号

191732-72-6

纯度

>98%

形式

Solid

form

分子量

259.26 Da

分子式

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>3</sub>N<sub>3</sub>O<sub>3</sub>

PubChem

216326

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生化试剂名称

Lenalidomide

生物学描述

Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.

经典 SMILES

C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

InChi

InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChiKey

GOTYRUGSSMKFNF-UHFFFAOYSA-N

IUPAC 名

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

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搭配使用产品

Biochemicals

AB141398

Cisplatin, antineoplastic agent

Chemical Structure - Cisplatin, antineoplastic agent (AB141398)

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Assay Kits

AB112136

Lysosomal Staining Kit - Green Fluorescence - Cytopainter

Fluorescence Microscopy - Lysosomal Staining Kit - Green Fluorescence - Cytopainter (AB112136)

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  • 0
Assay Kits

AB288318

Substance P ELISA Kit

  • 0
  • 0
Sample Prep & Detection Kits

AB267479

Exosome Isolation and Analysis Kit - Flow Cytometry, Plasma (CD9 / CD81)

Flow Cytometry - Exosome Isolation and Analysis Kit - Flow Cytometry, Plasma (CD9 / CD81) (AB267479)

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产品详情

This product is manufactured by BioVision, an Abcam company and was previously called 1862 (R,S)-Lenalidomide. 1862-100 is the same size as the 100 mg size of ab142129.
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Ikaros also known as IKZF1 is a zinc finger transcription factor with a mass of around 58 kDa. It is important for the development and function of the immune system specifically impacting lymphocyte differentiation. Ikaros is prominently expressed in hematopoietic cells including both B and T lymphocytes. IKZF3 another member of the Ikaros family serves similar roles while cereblon (CRBN) is part of the E3 ubiquitin ligase complex. CRBN is not a transcription factor but functions in protein ubiquitination and is expressed in multiple tissues suggesting diverse functions across different biological contexts.
Biological function summary

Ikaros and IKZF3 act as transcriptional regulators shaping lymphocyte gene expression in the immune system. They form complexes with other proteins to exert their regulatory effects on chromatin and transcription. CRBN as a substrate receptor for the CUL4-RBX1-DDB1-CRBN E3 ubiquitin ligase complex influences protein degradation pathways. It does not directly regulate transcription but plays a part in controlling protein turnover which can have regulatory impacts on cell signaling pathways.

Pathways

The significance of Ikaros and IKZF3 extends to the JAK-STAT signaling and B-cell receptor signaling pathways. In these pathways their transcriptional regulation affects gene expression critical for immune cell function. CRBN's role through ubiquitination connects indirectly to these pathways by modulating protein stability. Together they interact within complex networks of protein regulation influencing cellular responses to external stimuli.

Ikaros and IKZF3 are linked to hematologic malignancies such as leukemia. These transcription factors' mutations or dysregulation can lead to uncontrolled cell proliferation. The connection of CRBN to diseases like multiple myeloma comes from its interaction with the drug lenalidomide a derivative of thalidomide which modulates the immune response by degrading IKZF proteins. These interactions highlight the therapeutic targeting potential of CRBN in relation to drug efficacy and disease modulation.
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产品实验方案

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107059 PubMed37360684

2023

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.

Applications

Unspecified application

Species

Unspecified reactive species

Habib Bouguenina,Stephanos Nicolaou,Yann-Vaï Le Bihan,Elizabeth A Bowling,Cheyenne Calderon,John J Caldwell,Brinley Harrington,Angela Hayes,P Craig McAndrew,Costas Mitsopoulos,Fernando Jr Sialana,Andrea Scarpino,Mark Stubbs,Arjun Thapaliya,Siddhartha Tyagi,Hannah Z Wang,Francesca Wood,Rosemary Burke,Florence Raynaud,Jyoti Choudhary,Rob L M van Montfort,Amine Sadok,Thomas F Westbrook,Ian Collins,Rajesh Chopra
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