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AB146679

(R,S)-AMPA (mM/ml), AMPA agonist

(R,S)-AMPA (mM/ml), AMPA agonist

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MW 186.17 Da, Purity >99%. Prototypic agonist for AMPA receptors. Achieve your results faster with highly validated, pure and trusted compounds.

查看别名

AMPA 1, AMPA 2, AMPA 3, AMPA 4, AMPA-selective glutamate receptor 1, AMPA-selective glutamate receptor 2, AMPA-selective glutamate receptor 3, AMPA-selective glutamate receptor 4, EEA3, Excitatory amino acid receptor 1, Excitatory amino acid receptor 2, Excitatory amino acid receptor 3, Excitatory amino acid receptor 4, Excitatory amino acid receptor 5, GLR 6, GLR 7, GLR5, GLUH1, GLUK3, GLUK6, GLUR4C, GRIA1_HUMAN, GRIA2_HUMAN, GRIA3_HUMAN, GRIA4_HUMAN, GRIK, GRIK1_HUMAN, GRIK2 protein, GRIK2_HUMAN, GRIK3_HUMAN, GRIK4_HUMAN, GRIK5_HUMAN, GluA 4, GluA1, GluA2, GluA3, GluK2, GluK4, GluK5, GluR 7a, GluR-1, GluR-2, GluR-3, GluR-4, GluR-5, GluR-6, GluR-7, GluR-A, GluR-B, GluR-C, GluR-D, GluR-K1, GluR-K2, GluR-K3, GluRgamma2, Glutamate ionotropic receptor AMPA type subunit 3, Glutamate receptor, Glutamate receptor 1, Glutamate receptor 2, Glutamate receptor 3, Glutamate receptor 4, Glutamate receptor 5, Glutamate receptor 6, Glutamate receptor 7, Glutamate receptor C, Glutamate receptor KA 1precursor, Glutamate receptor KA-1, Glutamate receptor KA-2, Glutamate receptor ionotrophic AMPA 3, Glutamate receptor ionotrophic AMPA 4, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic AMPA 2, Glutamate receptor ionotropic kainate 1, Glutamate receptor ionotropic kainate 2, Glutamate receptor ionotropic kainate 3, Glutamate receptor ionotropic kainate 4, Glutamate receptor ionotropic kainate 4 precursor, Glutamate receptor subunit 3, Glutamate receptor, ionotropic kainate 5 [Precursor], Glutamate receptor, ionotropic, AMPA 3, Glutamate receptor, ionotropic, kainate 5, Glutamate receptor, ionotropic, kainate 5 (gamma 2), HBGR1, HBGR2, Human glutamate receptor GLUR5, Ionotrophic Glutamate Receptor, Ionotropic Glutamate receptor 4, KA2, MGC118086, MGC133252, MRT6, MRX94, OTTHUMP00000045951, OTTHUMP00000096569, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, OTTHUMP00000231881, bA487F5.1, dJ1171F9.1, glutamate receptor form A, glutamate receptor form B, glutamate receptor form C, glutamate receptor form D, glutamate receptor form E, iGlu5, ionotropic kainate 1, ionotropic kainate 2, ionotropic kainate 3, ionotropic kainate 4, ionotropic kainate 5

关键信息

CAS 号

77521-29-0

纯度

>99%

形式

Solid

form

分子量

186.17 Da

分子式

C<sub>7</sub>H<sub>1</sub><sub>0</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

1221

属性

Synthetic

生化试剂名称

alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID

生物学描述

Prototypic agonist for AMPA receptors.

经典 SMILES

CC1=C(C(=O)NO1)CC(C(=O)O)N

InChi

InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)

InChiKey

UUDAMDVQRQNNHZ-UHFFFAOYSA-N

IUPAC 名

2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid

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搭配使用产品

Biochemicals

AB146698

NMDA (mM/ml), excitotoxic amino acid

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Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 75
Biochemicals

AB275359

4-Hydrazino-7-nitrobenzofurazane hydrazine adduct

Chemical Structure - 4-Hydrazino-7-nitrobenzofurazane hydrazine adduct (AB275359)

  • 0
  • 0
Biochemicals

AB215116

Kifunensine, class I alpha-mannosidase inhibitor

Chemical Structure - Kifunensine, class I alpha-mannosidase inhibitor (AB215116)

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  • 0
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glutamate Receptor 1 (GluR1) also known as AMPA Receptor along with other subtypes like KA1 GluK2 GluA3 and GluA4 is a protein complex responsible for mediating fast synaptic transmission in the central nervous system. These receptors are ionotropic glutamate receptors and they are activated when the neurotransmitter glutamate binds to them. The activation allows the flow of sodium and calcium ions through the channel leading to excitatory postsynaptic potentials. The mass of AMPA receptors varies commonly around 100 kDa. These receptors are expressed in different regions of the brain for example the hippocampus and cerebral cortex which are areas important for memory processes.
Biological function summary

These receptors play an essential role in synaptic plasticity which is the cellular basis for learning and memory. They may form part of larger protein complexes that influence their trafficking and function in the neuronal membrane. The AMPA receptors interact with auxiliary proteins like stargazin which help in proper surface expression and synaptic localization. The ionotropic glutamate receptors establish the initial synaptic response setting off further events in excitatory neurotransmission that contribute to cognitive functions.

Pathways

Glutamate receptors like AMPA and kainate subtypes are involved in the glutamatergic signaling pathway. This pathway plays a pivotal role in propagating excitatory signals across neurons. Important proteins related to this pathway include NMDA receptors which in combination with AMPA receptors modulate synaptic strength and plasticity. The intracellular signaling cascade resulting from receptor activation can also involve calcium-calmodulin-dependent protein kinase (CaMKII) an important player in the longer-term changes in synaptic efficacy.

These receptors have significant involvement in neurodegenerative diseases like Alzheimer's and neurological conditions such as epilepsy. In Alzheimer's the improper regulation of synaptic AMPA receptor expression may lead to synaptic failure and cognitive impairment. Dysregulation of AMPA receptors is also associated with epileptic activity where excessive excitation can result in seizures. Understanding these interactions might offer potential therapeutic targets; for instance modulating NMDA and AMPA receptor activity can prove valuable in alleviating symptoms or slowing disease progression.
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产品实验方案

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